Method for detection of antibodies for metallic elements
Abstract
An apparatus and method for detecting antibodies specific to non-protein antigens. The apparatus is an immunological plate containing a plurality of plastic projections coated with a non-protein material. Assays utilizing the plate are capable of stabilizing the non-protein antigens with detection levels for antibodies specific to the antigens on a nanogram level. A screening assay with the apparatus allows for early detection of exposure to non-protein materials. Specifically metallic elements are detected.
- Inventors:
-
- Golden, CO
- Larkspur, CO
- Issue Date:
- Research Org.:
- Rockwell International Corp., Canoga Park, CA (United States)
- OSTI Identifier:
- 869042
- Patent Number(s):
- 5266499
- Application Number:
- 07/856,105
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- DOE Contract Number:
- AC04-76DP03533
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; detection; antibodies; metallic; elements; apparatus; detecting; specific; non-protein; antigens; immunological; plate; containing; plurality; plastic; projections; coated; material; assays; utilizing; capable; stabilizing; levels; nanogram; level; screening; assay; allows; exposure; materials; specifically; detected; plate containing; nanogram level; apparatus allows; metallic elements; antibodies specific; metallic element; /436/422/
Citation Formats
Barrick, Charles W, Clarke, Sara M, and Nordin, Carl W. Method for detection of antibodies for metallic elements. United States: N. p., 1993.
Web.
Barrick, Charles W, Clarke, Sara M, & Nordin, Carl W. Method for detection of antibodies for metallic elements. United States.
Barrick, Charles W, Clarke, Sara M, and Nordin, Carl W. Tue .
"Method for detection of antibodies for metallic elements". United States. https://www.osti.gov/servlets/purl/869042.
@article{osti_869042,
title = {Method for detection of antibodies for metallic elements},
author = {Barrick, Charles W and Clarke, Sara M and Nordin, Carl W},
abstractNote = {An apparatus and method for detecting antibodies specific to non-protein antigens. The apparatus is an immunological plate containing a plurality of plastic projections coated with a non-protein material. Assays utilizing the plate are capable of stabilizing the non-protein antigens with detection levels for antibodies specific to the antigens on a nanogram level. A screening assay with the apparatus allows for early detection of exposure to non-protein materials. Specifically metallic elements are detected.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {11}
}
Works referenced in this record:
A novel enzyme-linked immunosorbent assay (ELISA) for the detection of beryllium antibodies
journal, March 1991
- Clarke, S. M.
- Journal of Immunological Methods, Vol. 137, Issue 1