Method for detection of antibodies for metallic elements

Barrick, Charles W; Clarke, Sara M; Nordin, Carl W

Title: Method for detection of antibodies for metallic elements

Abstract

An apparatus and method for detecting antibodies specific to non-protein antigens. The apparatus is an immunological plate containing a plurality of plastic projections coated with a non-protein material. Assays utilizing the plate are capable of stabilizing the non-protein antigens with detection levels for antibodies specific to the antigens on a nanogram level. A screening assay with the apparatus allows for early detection of exposure to non-protein materials. Specifically metallic elements are detected.

Inventors:

Barrick, Charles W ^[1]; Clarke, Sara M ^[2]; Nordin, Carl W ^[1]

Golden, CO
Larkspur, CO

Issue Date:: 1993-11-30

Research Org.:: Rockwell International Corp., Canoga Park, CA (United States)

OSTI Identifier:: 869042

Patent Number(s):: 5266499

Application Number:: 07/856,105

Assignee:: United States of America as represented by United States (Washington, DC)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/553 - Metal or metal coated
G01N33/5308 - {for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S436/809 - Multifield plates or multicontainer arrays
Y10S436/81 - Tube, bottle, or dipstick

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DOE Contract Number:: AC04-76DP03533

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: method; detection; antibodies; metallic; elements; apparatus; detecting; specific; non-protein; antigens; immunological; plate; containing; plurality; plastic; projections; coated; material; assays; utilizing; capable; stabilizing; levels; nanogram; level; screening; assay; allows; exposure; materials; specifically; detected; plate containing; nanogram level; apparatus allows; metallic elements; antibodies specific; metallic element; /436/422/

Citation Formats


                    Barrick, Charles W, Clarke, Sara M, and Nordin, Carl W. Method for detection of antibodies for metallic elements.  United States: N. p., 1993. 
        Web.

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                    Barrick, Charles W, Clarke, Sara M, & Nordin, Carl W. Method for detection of antibodies for metallic elements.  United States.

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                    Barrick, Charles W, Clarke, Sara M, and Nordin, Carl W. Tue .  
        "Method for detection of antibodies for metallic elements".  United States.  https://www.osti.gov/servlets/purl/869042.

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@article{osti_869042,

  title        = {Method for detection of antibodies for metallic elements},

  author       = {Barrick, Charles W and Clarke, Sara M and Nordin, Carl W},

  abstractNote = {An apparatus and method for detecting antibodies specific to non-protein antigens. The apparatus is an immunological plate containing a plurality of plastic projections coated with a non-protein material. Assays utilizing the plate are capable of stabilizing the non-protein antigens with detection levels for antibodies specific to the antigens on a nanogram level. A screening assay with the apparatus allows for early detection of exposure to non-protein materials. Specifically metallic elements are detected.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1993},

  month        = {11}

}

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Works referenced in this record:

A novel enzyme-linked immunosorbent assay (ELISA) for the detection of beryllium antibodies
journal, March 1991

Clarke, S. M.
Journal of Immunological Methods, Vol. 137, Issue 1
https://doi.org/10.1016/0022-1759(91)90394-U

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Title: Method for detection of antibodies for metallic elements

Abstract

Citation Formats

A novel enzyme-linked immunosorbent assay (ELISA) for the detection of beryllium antibodies journal, March 1991

A novel enzyme-linked immunosorbent assay (ELISA) for the detection of beryllium antibodies
journal, March 1991