Method for detection of antibodies for metallic elements

Title: Method for detection of antibodies for metallic elements

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An apparatus and method for detecting antibodies specific to non-protein antigens. The apparatus is an immunological plate containing a plurality of plastic projections coated with a non-protein material. Assays utilizing the plate are capable of stabilizing the non-protein antigens with detection levels for antibodies specific to the antigens on a nanogram level. A screening assay with the apparatus allows for early detection of exposure to non-protein materials. Specifically metallic elements are detected.

Inventors:

Barrick, Charles W. ^[1]; Clarke, Sara M. ^[2]; Nordin, Carl W. ^[1]

(Golden, CO)
(Larkspur, CO)

Issue Date:: 1993-11-30

OSTI Identifier:: 869042

Assignee:: United States of America as represented by United States (Washington, DC) SNL

Patent Number(s):: US 5266499

Application Number:: 07/856,105

Contract Number:: AC04-76DP03533

Research Org:: ROCKWELL INTERNATIONAL CORP

Country of Publication:: United States

Language:: English

Subject:: method; detection; antibodies; metallic; elements; apparatus; detecting; specific; non-protein; antigens; immunological; plate; containing; plurality; plastic; projections; coated; material; assays; utilizing; capable; stabilizing; levels; nanogram; level; screening; assay; allows; exposure; materials; specifically; detected; plate containing; nanogram level; apparatus allows; metallic elements; antibodies specific; metallic element; /436/422/

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