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Title: Detection and differentiation of coxiella burnetii in biological fluids

Abstract

Methods for detecting the presence of Coxiella burnetii in biological samples, as well as a method for differentiating strains of C. burnetii that are capable of causing acute disease from those strains capable of causing chronic disease are disclosed. The methods generally comprise treating cells contained within the biological sample to expose cellular DNA, and hybridizing the cellular DNA with a DNA probe containing DNA sequences that specifically hybridize with C. burnetii DNA of strains associated with the capacity to cause acute or chronic disease.

Inventors:
 [1];  [2];  [3];  [4]
  1. (Richland, WA)
  2. (Moscow, ID)
  3. (Derwood, MD)
  4. (Albuquerque, NM)
Issue Date:
Research Org.:
BATTELLE MEMORIAL INSTITUTE
OSTI Identifier:
868995
Patent Number(s):
5258283
Assignee:
Battelle Memorial Institute (Richland, WA) PNNL
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
detection; differentiation; coxiella; burnetii; biological; fluids; methods; detecting; presence; samples; method; differentiating; strains; capable; causing; acute; disease; chronic; disclosed; comprise; treating; cells; contained; sample; expose; cellular; dna; hybridizing; probe; containing; sequences; specifically; hybridize; associated; capacity; biological samples; dna sequences; dna sequence; cellular dna; biological fluids; treating cells; strains capable; biological fluid; comprise treating; acute disease; causing acute; causing chronic; coxiella burnetii; biological sample; cells contained; chronic disease; dna probe; expose cellular; differentiating strains; cells contain; /435/436/999/

Citation Formats

Frazier, Marvin E., Mallavia, Louis P., Samuel, James E., and Baca, Oswald G. Detection and differentiation of coxiella burnetii in biological fluids. United States: N. p., 1993. Web.
Frazier, Marvin E., Mallavia, Louis P., Samuel, James E., & Baca, Oswald G. Detection and differentiation of coxiella burnetii in biological fluids. United States.
Frazier, Marvin E., Mallavia, Louis P., Samuel, James E., and Baca, Oswald G. Fri . "Detection and differentiation of coxiella burnetii in biological fluids". United States. https://www.osti.gov/servlets/purl/868995.
@article{osti_868995,
title = {Detection and differentiation of coxiella burnetii in biological fluids},
author = {Frazier, Marvin E. and Mallavia, Louis P. and Samuel, James E. and Baca, Oswald G.},
abstractNote = {Methods for detecting the presence of Coxiella burnetii in biological samples, as well as a method for differentiating strains of C. burnetii that are capable of causing acute disease from those strains capable of causing chronic disease are disclosed. The methods generally comprise treating cells contained within the biological sample to expose cellular DNA, and hybridizing the cellular DNA with a DNA probe containing DNA sequences that specifically hybridize with C. burnetii DNA of strains associated with the capacity to cause acute or chronic disease.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {1}
}

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