Antibody-mediated cofactor-driven reactions
Abstract
Chemical reactions capable of being rate-enhanced by auxiliary species which interact with the reactants but do not become chemically bound to them in the formation of the final product are performed in the presence of antibodies which promote the reactions. The antibodies contain regions within their antigen binding sites which recognize the auxiliary species in a conformation which promotes the reaction. The antigen binding site frequently recognizes a particular transition state complex or other high energy complex along the reaction coordinate, thereby promoting the progress of the reaction along the desired route as opposed to other less favorable routes. Various classes of reaction together with appropriate antigen binding site specificities tailored for each are disclosed.
- Inventors:
-
- (Oakland, CA)
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
- OSTI Identifier:
- 868818
- Patent Number(s):
- 5219732
- Assignee:
- Regents of University of California (Oakland, CA) LBNL
- DOE Contract Number:
- C87-101226
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- antibody-mediated; cofactor-driven; reactions; chemical; capable; rate-enhanced; auxiliary; species; interact; reactants; chemically; bound; formation; final; product; performed; presence; antibodies; promote; contain; regions; antigen; binding; sites; recognize; conformation; promotes; reaction; site; frequently; recognizes; particular; transition; complex; energy; coordinate; promoting; progress; desired; route; opposed; favorable; routes; various; appropriate; specificities; tailored; disclosed; binding site; chemical reaction; chemical reactions; final product; binding sites; chemically bound; site specific; /435/
Citation Formats
Schultz, Peter G. Antibody-mediated cofactor-driven reactions. United States: N. p., 1993.
Web.
Schultz, Peter G. Antibody-mediated cofactor-driven reactions. United States.
Schultz, Peter G. Fri .
"Antibody-mediated cofactor-driven reactions". United States. https://www.osti.gov/servlets/purl/868818.
@article{osti_868818,
title = {Antibody-mediated cofactor-driven reactions},
author = {Schultz, Peter G.},
abstractNote = {Chemical reactions capable of being rate-enhanced by auxiliary species which interact with the reactants but do not become chemically bound to them in the formation of the final product are performed in the presence of antibodies which promote the reactions. The antibodies contain regions within their antigen binding sites which recognize the auxiliary species in a conformation which promotes the reaction. The antigen binding site frequently recognizes a particular transition state complex or other high energy complex along the reaction coordinate, thereby promoting the progress of the reaction along the desired route as opposed to other less favorable routes. Various classes of reaction together with appropriate antigen binding site specificities tailored for each are disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {1}
}