Antibody-mediated cofactor-driven reactions

Title: Antibody-mediated cofactor-driven reactions

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Abstract

Chemical reactions capable of being rate-enhanced by auxiliary species which interact with the reactants but do not become chemically bound to them in the formation of the final product are performed in the presence of antibodies which promote the reactions. The antibodies contain regions within their antigen binding sites which recognize the auxiliary species in a conformation which promotes the reaction. The antigen binding site frequently recognizes a particular transition state complex or other high energy complex along the reaction coordinate, thereby promoting the progress of the reaction along the desired route as opposed to other less favorable routes. Various classes of reaction together with appropriate antigen binding site specificities tailored for each are disclosed.

Inventors:

Schultz, Peter G ^[1]

Oakland, CA

Issue Date:: 1993-01-01

Research Org.:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

OSTI Identifier:: 868818

Patent Number(s):: 5219732

Assignee:: Regents of University of California (Oakland, CA)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

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C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C12P17/16 - containing two or more hetero rings {

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N9/0002 - {Antibodies with enzymatic activity, e.g. abzymes}

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C12P7/22 - aromatic
C12P17/00 - Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
C12P13/04 - Alpha- or beta- amino acids {
C12P13/02 - Amides, e.g. chloramphenicol {or polyamides
C12P13/001 - {Amines

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DOE Contract Number:: C87-101226

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: antibody-mediated; cofactor-driven; reactions; chemical; capable; rate-enhanced; auxiliary; species; interact; reactants; chemically; bound; formation; final; product; performed; presence; antibodies; promote; contain; regions; antigen; binding; sites; recognize; conformation; promotes; reaction; site; frequently; recognizes; particular; transition; complex; energy; coordinate; promoting; progress; desired; route; opposed; favorable; routes; various; appropriate; specificities; tailored; disclosed; binding site; chemical reaction; chemical reactions; final product; binding sites; chemically bound; site specific; /435/

Citation Formats


                    Schultz, Peter G. Antibody-mediated cofactor-driven reactions.  United States: N. p., 1993. 
        Web.

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                    Schultz, Peter G. Antibody-mediated cofactor-driven reactions.  United States.

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                    Schultz, Peter G. Fri .  
        "Antibody-mediated cofactor-driven reactions".  United States.  https://www.osti.gov/servlets/purl/868818.

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@article{osti_868818,

  title        = {Antibody-mediated cofactor-driven reactions},

  author       = {Schultz, Peter G},

  abstractNote = {Chemical reactions capable of being rate-enhanced by auxiliary species which interact with the reactants but do not become chemically bound to them in the formation of the final product are performed in the presence of antibodies which promote the reactions. The antibodies contain regions within their antigen binding sites which recognize the auxiliary species in a conformation which promotes the reaction. The antigen binding site frequently recognizes a particular transition state complex or other high energy complex along the reaction coordinate, thereby promoting the progress of the reaction along the desired route as opposed to other less favorable routes. Various classes of reaction together with appropriate antigen binding site specificities tailored for each are disclosed.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1993},

  month        = {1}

}

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