Title: Catalytic and reactive polypeptides and methods for their preparation and use

Abstract

Catalytic and reactive polypeptides include a binding site specific for a reactant or reactive intermediate involved in a chemical reaction of interest. The polypeptides further include at least one active functionality proximate the bi.

Inventors:

Schultz, Peter ^[1]

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1. Oakland, CA

Issue Date:

1993-01-01

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

OSTI Identifier:

868799

Patent Number(s):

5215889

Assignee:

Regents of University of California (Oakland, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K47/68 - the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61K47/6835 - {the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K16/00 - Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies {

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12N9/0002 - {Antibodies with enzymatic activity, e.g. abzymes}
C12N9/86 - acting on amide bonds in cyclic amides, e.g. penicillinase {

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DOE Contract Number:  

C87-101226

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

catalytic; reactive; polypeptides; methods; preparation; binding; site; specific; reactant; intermediate; involved; chemical; reaction; active; functionality; proximate; reactive polypeptides; binding site; chemical reaction; site specific; /435/530/