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Title: Method of measurement in biological systems

Abstract

Disclosed is a method of quantifying molecules in biological substances, comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering said chemical specie to said biological host in doses sufficiently low to avoid significant overt damage to the biological system thereof, d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host, e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources, f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in said material by means of direct isotopic counting.

Inventors:
 [1];  [2];  [3];  [4];  [1];  [1]
+ Show Inventor Affiliations
  1. Livermore, CA
  2. Union City, CA
  3. Danville, CA
  4. Alamo, CA
Issue Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
OSTI Identifier:
868782
Patent Number(s):
5209919
Application Number:
07/693,248
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; measurement; biological; systems; disclosed; quantifying; molecules; substances; comprising; selecting; host; radioisotopes; concentrations; equal; ambient; biosphere; preparing; long-lived; radioisotope; labeled; reactive; chemical; specie; administering; doses; sufficiently; avoid; significant; overt; damage; allowing; period; time; elapse; sufficient; dissemination; interaction; throughout; isolating; reacted; fraction; substance; manner; contamination; extraneous; sources; converting; suitable; means; material; efficiently; produces; charged; introduction; isotopic; fractionation; measuring; concentration; direct; counting; reactive chemical; suitable means; avoid contamination; biological substance; biological host; biological systems; chemical specie; reacted fraction; radioisotope labeled; radioisotope concentration; significant isotopic; significant overt; avoid significant; ambient biosphere; produces charged; manner sufficient; isotopic counting; overt damage; concentrations equal; biological substances; isotopic fractionation; long-lived radioisotope; quantifying molecules; extraneous sources; direct isotopic; efficiently produces; elapse sufficient; labeled reactive; doses sufficiently; host throughout; active chemical; isotope concentration; /424/250/436/600/

Citation Formats

Turteltaub, Kenneth W, Vogel, John S, Felton, James S, Gledhill, Barton L, Davis, Jay C, and Stanker, Larry H. Method of measurement in biological systems. United States: N. p., 1993. Web.
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Turteltaub, Kenneth W, Vogel, John S, Felton, James S, Gledhill, Barton L, Davis, Jay C, & Stanker, Larry H. Method of measurement in biological systems. United States.
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Turteltaub, Kenneth W, Vogel, John S, Felton, James S, Gledhill, Barton L, Davis, Jay C, and Stanker, Larry H. Tue . "Method of measurement in biological systems". United States. https://www.osti.gov/servlets/purl/868782.
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@article{osti_868782,
title = {Method of measurement in biological systems},
author = {Turteltaub, Kenneth W and Vogel, John S and Felton, James S and Gledhill, Barton L and Davis, Jay C and Stanker, Larry H},
abstractNote = {Disclosed is a method of quantifying molecules in biological substances, comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering said chemical specie to said biological host in doses sufficiently low to avoid significant overt damage to the biological system thereof, d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host, e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources, f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in said material by means of direct isotopic counting.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 11 00:00:00 EDT 1993},
month = {Tue May 11 00:00:00 EDT 1993}
}
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Works referenced in this record:

Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA.
journal, July 1990

Ultrasensitive Mass Spectrometry with Accelerators
journal, December 1980

Applications of Accelerator Mass Spectrometry
journal, May 1984

Memory Effects in an AMS System: Catastrophe and Recovery
journal, January 1990

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