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Title: Electromagnetic field triggered drug and chemical delivery via liposomes

Abstract

The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

Inventors:
 [1]
  1. 1820 Mountain View Rd., Tiburon, CA 94920
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
868683
Patent Number(s):
5190761
Assignee:
Liburdy, Robert P. (1820 Mountain View Rd., Tiburon, CA 94920)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
electromagnetic; field; triggered; drug; chemical; delivery; via; liposomes; relates; method; delivering; preselected; target; site; patient; comprising; steps; encapsulating; agent; essentially; temperature; insensitive; specific; predetermined; phase; transition; range; administration; administering; subjecting; nonionizing; fields; release; 10; 65; degree; bind; surface; enter; tissue; organ; living; subjected; target tissue; chemical agent; ionizing electromagnetic; electromagnetic fields; electromagnetic field; temperature range; magnetic field; magnetic fields; transition temperature; phase transition; chemical delivery; target site; selected target; temperature insensitive; /424/264/428/436/514/607/

Citation Formats

Liburdy, Robert P. Electromagnetic field triggered drug and chemical delivery via liposomes. United States: N. p., 1993. Web.
Liburdy, Robert P. Electromagnetic field triggered drug and chemical delivery via liposomes. United States.
Liburdy, Robert P. Fri . "Electromagnetic field triggered drug and chemical delivery via liposomes". United States. https://www.osti.gov/servlets/purl/868683.
@article{osti_868683,
title = {Electromagnetic field triggered drug and chemical delivery via liposomes},
author = {Liburdy, Robert P},
abstractNote = {The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {1}
}

Works referenced in this record:

Treatment of Murine SCC VII Tumors with Localized Hyperthermia and Temperature-Sensitive Liposomes Containing Cisplatin
journal, May 1990


Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction
journal, April 1968


Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes
journal, November 1989


The effect of cholesterol incorporation on the temperature dependence of water permeation through liposomal membranes prepared from phosphatidylcholines
journal, February 1977


Design of liposomes for enhanced local release of drugs by hyperthermia
journal, December 1978


Effect of 2.45 GHz microwave radiation on permeability of unilamellar liposomes to 5(6)-carboxyfluorescein. Evidence of non-thermal leakage
journal, April 1991


Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors
journal, April 1979


Microwave-Stimulated Drug Release from Liposomes
journal, August 1985