Electromagnetic field triggered drug and chemical delivery via liposomes
Abstract
The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.
- Inventors:
-
- 1820 Mountain View Rd., Tiburon, CA 94920
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- OSTI Identifier:
- 868683
- Patent Number(s):
- 5190761
- Assignee:
- Liburdy, Robert P. (1820 Mountain View Rd., Tiburon, CA 94920)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- electromagnetic; field; triggered; drug; chemical; delivery; via; liposomes; relates; method; delivering; preselected; target; site; patient; comprising; steps; encapsulating; agent; essentially; temperature; insensitive; specific; predetermined; phase; transition; range; administration; administering; subjecting; nonionizing; fields; release; 10; 65; degree; bind; surface; enter; tissue; organ; living; subjected; target tissue; chemical agent; ionizing electromagnetic; electromagnetic fields; electromagnetic field; temperature range; magnetic field; magnetic fields; transition temperature; phase transition; chemical delivery; target site; selected target; temperature insensitive; /424/264/428/436/514/607/
Citation Formats
Liburdy, Robert P. Electromagnetic field triggered drug and chemical delivery via liposomes. United States: N. p., 1993.
Web.
Liburdy, Robert P. Electromagnetic field triggered drug and chemical delivery via liposomes. United States.
Liburdy, Robert P. Fri .
"Electromagnetic field triggered drug and chemical delivery via liposomes". United States. https://www.osti.gov/servlets/purl/868683.
@article{osti_868683,
title = {Electromagnetic field triggered drug and chemical delivery via liposomes},
author = {Liburdy, Robert P},
abstractNote = {The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {1}
}
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