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Title: Methods for tritium labeling

Abstract

Reagents and processes for reductively introducing deuterium or tritium into organic molecules are described. The reagents are deuterium or tritium analogs of trialkyl boranes, borane or alkali metal aluminum hydrides. The process involves forming these reagents in situ from alkali metal tritides or deuterides.

Inventors:
 [1];  [2];  [3]
  1. Hochwald, CH
  2. El Cerrito, CA
  3. Oakland, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
OSTI Identifier:
868660
Patent Number(s):
5186868
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
methods; tritium; labeling; reagents; processes; reductively; introducing; deuterium; organic; molecules; described; analogs; trialkyl; boranes; borane; alkali; metal; aluminum; hydrides; process; involves; forming; situ; tritides; deuterides; organic molecules; process involves; alkali metal; involves forming; metal aluminum; organic molecule; tritium labeling; /252/423/

Citation Formats

Andres, Hendrik, Morimoto, Hiromi, and Williams, Philip G. Methods for tritium labeling. United States: N. p., 1993. Web.
Andres, Hendrik, Morimoto, Hiromi, & Williams, Philip G. Methods for tritium labeling. United States.
Andres, Hendrik, Morimoto, Hiromi, and Williams, Philip G. Fri . "Methods for tritium labeling". United States. https://www.osti.gov/servlets/purl/868660.
@article{osti_868660,
title = {Methods for tritium labeling},
author = {Andres, Hendrik and Morimoto, Hiromi and Williams, Philip G},
abstractNote = {Reagents and processes for reductively introducing deuterium or tritium into organic molecules are described. The reagents are deuterium or tritium analogs of trialkyl boranes, borane or alkali metal aluminum hydrides. The process involves forming these reagents in situ from alkali metal tritides or deuterides.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {1}
}

Works referenced in this record:

2. The formation of alkali-metal hydrides by atomic hydrogen
journal, January 1934


Lithium perhydro-9b-boraphenalylhydride. Active reducing agent of unusually high stereoselectivity for the reduction of cyclic and bicyclic ketones
journal, February 1970


Preparation and use of LiEt3Bt and LiAlT4 at maximum specific activity
journal, January 1990


Representative metalation and reduction reactions of the superactive metal hydrides, LiH, NaH, and KH
journal, September 1987


The laboratory preparation of lithium deuteride and lithium aluminium deuteride
journal, May 1958


Stereospecific synthesis of 1,4-dienes by cross-coupling of allyl halides with alkenylcopper intermediates from alkenyldialkylboranes
journal, February 1980


Application of modern tritium NMR techniques to analysis of complex isotopic products from a hydrogenation reaction
journal, November 1988


REACTIONS OF TRITIUM ATOMS WITH FROZEN CYCLOPROPANE 1
journal, November 1962


Lithium triethylborohydride. Exceptionally powerful nucleophile in displacement reactions with organic halides
journal, March 1973


Lithium triethylborotritide (super-tritide): a useful reagent for tritium labelling
journal, January 1983


Density of trapped gas in heavily-irradiated lithium hydride
journal, July 1988


Superactive Alkali Metal Hydride Metalation Reagents: LiH, NaH, and KH
journal, May 1986


Tritium nuclear magnetic resonance spectroscopy. 14—analysis of tritiated methyl groups
journal, February 1981


Isotopic exchange of gaseous deuterium with lattice hydrogen of hydrides
journal, January 1971