Rotor assembly and method for automatically processing liquids

Title: Rotor assembly and method for automatically processing liquids

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Abstract

A rotor assembly for performing a relatively large number of processing steps upon a sample, such as a whole blood sample, and a diluent, such as water, includes a rotor body for rotation about an axis and including a network of chambers within which various processing steps are performed upon the sample and diluent and passageways through which the sample and diluent are transferred. A transfer mechanism is movable through the rotor body by the influence of a magnetic field generated adjacent the transfer mechanism and movable along the rotor body, and the assembly utilizes centrifugal force, a transfer of momentum and capillary action to perform any of a number of processing steps such as separation, aliquoting, transference, washing, reagent addition and mixing of the sample and diluent within the rotor body. The rotor body is particularly suitable for automatic immunoassay analyses.

Inventors:

Burtis, Carl A ^[1]; Johnson, Wayne F ^[2]; Walker, William A ^[3]

Oak Ridge, TN
Loudon, TN
Knoxville, TN

Issue Date:: 1992-01-01

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:: 868602

Patent Number(s):: 5173262

Assignee:: Martin Marietta Energy Systems, Inc. (Oak Ridge, TN)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L3/502753 - {characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N21/07 - Centrifugal type cuvettes

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L3/502738 - {characterised by integrated valves

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/25375 - Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L2400/0409 - centrifugal forces

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/111666 - Utilizing a centrifuge or compartmented rotor

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L2300/0803 - Disc shape
B01L2300/0864 - comprising only one inlet and multiple receiving wells, e.g. for separation, splitting

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/491 - {by separating the blood components

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/2575 - Volumetric liquid transfer

B - PERFORMING OPERATIONS B04 - CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES B04B - CENTRIFUGES
B04B5/0414 - {comprising test tubes}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L2400/065 - sliding valves

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DOE Contract Number:: AC05-84OR21400

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: rotor; assembly; method; automatically; processing; liquids; performing; relatively; steps; sample; blood; diluent; water; rotation; axis; including; network; chambers; various; performed; passageways; transferred; transfer; mechanism; movable; influence; magnetic; field; generated; adjacent; utilizes; centrifugal; force; momentum; capillary; action; perform; separation; aliquoting; transference; washing; reagent; addition; mixing; particularly; suitable; automatic; immunoassay; analyses; blood sample; centrifugal force; rotor assembly; particularly suitable; magnetic field; processing steps; field generated; capillary action; assembly utilizes; processing step; processing liquids; transfer mechanism; /422/436/494/

Citation Formats


                    Burtis, Carl A, Johnson, Wayne F, and Walker, William A. Rotor assembly and method for automatically processing liquids.  United States: N. p., 1992. 
        Web.

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                    Burtis, Carl A, Johnson, Wayne F, & Walker, William A. Rotor assembly and method for automatically processing liquids.  United States.

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                    Burtis, Carl A, Johnson, Wayne F, and Walker, William A. Wed .  
        "Rotor assembly and method for automatically processing liquids".  United States.  https://www.osti.gov/servlets/purl/868602.

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@article{osti_868602,

  title        = {Rotor assembly and method for automatically processing liquids},

  author       = {Burtis, Carl A and Johnson, Wayne F and Walker, William A},

  abstractNote = {A rotor assembly for performing a relatively large number of processing steps upon a sample, such as a whole blood sample, and a diluent, such as water, includes a rotor body for rotation about an axis and including a network of chambers within which various processing steps are performed upon the sample and diluent and passageways through which the sample and diluent are transferred. A transfer mechanism is movable through the rotor body by the influence of a magnetic field generated adjacent the transfer mechanism and movable along the rotor body, and the assembly utilizes centrifugal force, a transfer of momentum and capillary action to perform any of a number of processing steps such as separation, aliquoting, transference, washing, reagent addition and mixing of the sample and diluent within the rotor body. The rotor body is particularly suitable for automatic immunoassay analyses.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1992},

  month        = {1}

}

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