Rotor assembly and method for automatically processing liquids

Burtis, Carl A; Johnson, Wayne F; Walker, William A

Title: Rotor assembly and method for automatically processing liquids

Abstract

A rotor assembly for performing a relatively large number of processing steps upon a sample, such as a whole blood sample, and a diluent, such as water, includes a rotor body for rotation about an axis and including a network of chambers within which various processing steps are performed upon the sample and diluent and passageways through which the sample and diluent are transferred. A transfer mechanism is movable through the rotor body by the influence of a magnetic field generated adjacent the transfer mechanism and movable along the rotor body, and the assembly utilizes centrifugal force, a transfer of momentum and capillary action to perform any of a number of processing steps such as separation, aliquoting, transference, washing, reagent addition and mixing of the sample and diluent within the rotor body. The rotor body is particularly suitable for automatic immunoassay analyses.

Inventors:

Burtis, Carl A ^[1]; Johnson, Wayne F ^[2]; Walker, William A ^[3]

Oak Ridge, TN
Loudon, TN
Knoxville, TN

Issue Date:: 1992-01-01

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:: 868602

Patent Number(s):: 5173262

Assignee:: Martin Marietta Energy Systems, Inc. (Oak Ridge, TN)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

Show more

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N21/07 - Centrifugal type cuvettes

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L3/502753 - {characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
B01L3/502738 - {characterised by integrated valves

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/25375 - Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Y10T436/111666 - Utilizing a centrifuge or compartmented rotor

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L2400/0409 - centrifugal forces
B01L2300/0864 - comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
B01L2300/0803 - Disc shape

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/2575 - Volumetric liquid transfer

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/491 - {by separating the blood components

B - PERFORMING OPERATIONS B04 - CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES B04B - CENTRIFUGES
B04B5/0414 - {comprising test tubes}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L2400/065 - sliding valves

Show less

DOE Contract Number:: AC05-84OR21400

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: rotor; assembly; method; automatically; processing; liquids; performing; relatively; steps; sample; blood; diluent; water; rotation; axis; including; network; chambers; various; performed; passageways; transferred; transfer; mechanism; movable; influence; magnetic; field; generated; adjacent; utilizes; centrifugal; force; momentum; capillary; action; perform; separation; aliquoting; transference; washing; reagent; addition; mixing; particularly; suitable; automatic; immunoassay; analyses; blood sample; centrifugal force; rotor assembly; particularly suitable; magnetic field; processing steps; field generated; capillary action; assembly utilizes; processing step; processing liquids; transfer mechanism; /422/436/494/

Citation Formats


                    Burtis, Carl A, Johnson, Wayne F, and Walker, William A. Rotor assembly and method for automatically processing liquids.  United States: N. p., 1992. 
        Web.

Copy to clipboard


                    Burtis, Carl A, Johnson, Wayne F, & Walker, William A. Rotor assembly and method for automatically processing liquids.  United States.

Copy to clipboard


                    Burtis, Carl A, Johnson, Wayne F, and Walker, William A. Wed .  
        "Rotor assembly and method for automatically processing liquids".  United States.  https://www.osti.gov/servlets/purl/868602.

Copy to clipboard


                    
@article{osti_868602,

  title        = {Rotor assembly and method for automatically processing liquids},

  author       = {Burtis, Carl A and Johnson, Wayne F and Walker, William A},

  abstractNote = {A rotor assembly for performing a relatively large number of processing steps upon a sample, such as a whole blood sample, and a diluent, such as water, includes a rotor body for rotation about an axis and including a network of chambers within which various processing steps are performed upon the sample and diluent and passageways through which the sample and diluent are transferred. A transfer mechanism is movable through the rotor body by the influence of a magnetic field generated adjacent the transfer mechanism and movable along the rotor body, and the assembly utilizes centrifugal force, a transfer of momentum and capillary action to perform any of a number of processing steps such as separation, aliquoting, transference, washing, reagent addition and mixing of the sample and diluent within the rotor body. The rotor body is particularly suitable for automatic immunoassay analyses.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1992},

  month        = {1}

}

Copy to clipboard

Patent:

View Patent

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Two-dimensional centrifugation for desk-top clinical chemistry.
journal, September 1985

Schultz, S. G.; Holen, J. T.; Donohue, J. P.
Clinical Chemistry, Vol. 31, Issue 9
https://doi.org/10.1093/clinchem/31.9.1457

Development of a simple device for processing whole-blood samples into measured aliquots of plasma.
journal, September 1986

Burtis, C. A.; Johnson, W. F.; Walker, W. A.
Clinical Chemistry, Vol. 32, Issue 9
https://doi.org/10.1093/clinchem/32.9.1642

Similar Records in DOE Patents and OSTI.GOV collections:

Rotor assembly and method for automatically processing liquids

Patent Burtis, C A; Johnson, W F; Walker, W A

A rotor assembly is described for performing a relatively large number of processing steps upon a sample, such as a whole blood sample, and a diluent, such as water. It includes a rotor body for rotation about an axis and includes a network of chambers within which various processing steps are performed upon the sample and diluent and passageways through which the sample and diluent are transferred. A transfer mechanism is movable through the rotor body by the influence of a magnetic field generated adjacent the transfer mechanism and movable along the rotor body, and the assembly utilizes centrifugal force,more »« less
Method and apparatus for assembling permanent magnet rotors

Patent Hsu, John S [Oak Ridge, TN]; Adams, Donald J [Knoxville, TN]

A permanent magnet assembly (22) for assembly in large permanent magnet (PM) motors and generators includes a two-piece carrier (23, 24) that can be slid into a slot (13) in the rotor (10) and then secured in place using a set screw (37). The invention also provides an auxiliary carrier device (50) with guide rails (51) that line up with the teeth (12) of the rotor, so that a permanent magnet assembly (22) can be pushed first into a slot (13), and then down the slot (13) to its proper location. An auxiliary tool (50) is provided to move themore »« less
Full Text Available
Rotor assembly and assay method

Patent Burtis, Carl A [Oak Ridge, TN]; Johnson, Wayne F [Loudon, TN]; Walker, William A [Knoxville, TN]

A rotor assembly for carrying out an assay includes a rotor body which is rotatable about an axis of rotation, and has a central chamber and first, second, third, fourth, fifth, and sixth chambers which are in communication with and radiate from the central chamber. The rotor assembly further includes a shuttle which is movable through the central chamber and insertable into any of the chambers, the shuttle including a reaction cup carrying an immobilized antigen or an antibody for transport among the chambers. A method for carrying out an assay using the rotor assembly includes moving the reaction cupmore »« less
Full Text Available
Rotor for processing liquids using movable capillary tubes

Patent Johnson, Wayne F [Loudon, TN]; Burtis, Carl A [Oak Ridge, TN]; Walker, William A [Knoxville, TN]

A rotor assembly for processing liquids, especially whole blood samples, is disclosed. The assembly includes apparatus for separating non-liquid components of whole blood samples from liquid components, apparatus for diluting the separated liquid component with a diluent and apparatus for transferring the diluted sample to an external apparatus for analysis. The rotor assembly employs several movable capillary tubes to handle the sample and diluents. A method for using the rotor assembly to process liquids is also described.
Full Text Available
Systems and methods for control of polymer reactions and processing using automatic continuous online monitoring

Patent Reed, Wayne Frederick; Drenski, Michael Felix

Manual and automatic methods and devices using a ACOMP system for active control of polymerization reaction processes. An ideal desired trajectory of one or more reaction and polymer characteristics can be established to produce a desired final polymer product with specified characteristics from a polymerization reaction process. A current reaction trajectory of a polymerization reaction process can be driven to an ideal or desired reaction trajectory. In a manual embodiment an operator can use ACOMP data to adjust process variables in order to drive the current reaction trajectory toward the ideal or desired reaction trajectory. In an automated mode amore »« less
Full Text Available

Similar Records

Title: Rotor assembly and method for automatically processing liquids

Abstract

Citation Formats

Two-dimensional centrifugation for desk-top clinical chemistry. journal, September 1985

Development of a simple device for processing whole-blood samples into measured aliquots of plasma. journal, September 1986

Two-dimensional centrifugation for desk-top clinical chemistry.
journal, September 1985

Development of a simple device for processing whole-blood samples into measured aliquots of plasma.
journal, September 1986