skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: 2' and 3' Carboranyl uridines and their diethyl ether adducts

Abstract

There is disclosed a process for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron containing nucleoside compounds. Said carboranyl uridine nucleoside compounds exhibit enhanced lipophilicity and hydrophilic properties adequate to enable solvation in aqueous media for subsequent incorporation of said compounds in methods for boron neutron capture therapy in mammalian tumor cells.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
The Ohio State Univ., Columbus, OH (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
868594
Patent Number(s):
5171849
Application Number:
07/688,121
Assignee:
Ohio State University Research Foundation (Columbus, OH)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
DOE Contract Number:  
FG02-90ER60972
Resource Type:
Patent
Resource Relation:
Patent File Date: 1991 Apr 19
Country of Publication:
United States
Language:
English
Subject:
/999/514/

Citation Formats

Soloway, Albert H., Barth, Rolf F., Anisuzzaman, Abul K., Alam, Fazlul, and Tjarks, Werner. 2' and 3' Carboranyl uridines and their diethyl ether adducts. United States: N. p., 1992. Web.
Soloway, Albert H., Barth, Rolf F., Anisuzzaman, Abul K., Alam, Fazlul, & Tjarks, Werner. 2' and 3' Carboranyl uridines and their diethyl ether adducts. United States.
Soloway, Albert H., Barth, Rolf F., Anisuzzaman, Abul K., Alam, Fazlul, and Tjarks, Werner. Wed . "2' and 3' Carboranyl uridines and their diethyl ether adducts". United States. https://www.osti.gov/servlets/purl/868594.
@article{osti_868594,
title = {2' and 3' Carboranyl uridines and their diethyl ether adducts},
author = {Soloway, Albert H. and Barth, Rolf F. and Anisuzzaman, Abul K. and Alam, Fazlul and Tjarks, Werner},
abstractNote = {There is disclosed a process for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron containing nucleoside compounds. Said carboranyl uridine nucleoside compounds exhibit enhanced lipophilicity and hydrophilic properties adequate to enable solvation in aqueous media for subsequent incorporation of said compounds in methods for boron neutron capture therapy in mammalian tumor cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1992},
month = {1}
}

Patent:

Save / Share: