2' and 3' Carboranyl uridines and their diethyl ether adducts
Abstract
There is disclosed a process for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron containing nucleoside compounds. Said carboranyl uridine nucleoside compounds exhibit enhanced lipophilicity and hydrophilic properties adequate to enable solvation in aqueous media for subsequent incorporation of said compounds in methods for boron neutron capture therapy in mammalian tumor cells.
- Inventors:
- Issue Date:
- Research Org.:
- The Ohio State Univ., Columbus, OH (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 868594
- Patent Number(s):
- 5171849
- Application Number:
- 07/688,121
- Assignee:
- Ohio State University Research Foundation (Columbus, OH)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
- DOE Contract Number:
- FG02-90ER60972
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 1991 Apr 19
- Country of Publication:
- United States
- Language:
- English
- Subject:
- /999/514/
Citation Formats
Soloway, Albert H., Barth, Rolf F., Anisuzzaman, Abul K., Alam, Fazlul, and Tjarks, Werner. 2' and 3' Carboranyl uridines and their diethyl ether adducts. United States: N. p., 1992.
Web.
Soloway, Albert H., Barth, Rolf F., Anisuzzaman, Abul K., Alam, Fazlul, & Tjarks, Werner. 2' and 3' Carboranyl uridines and their diethyl ether adducts. United States.
Soloway, Albert H., Barth, Rolf F., Anisuzzaman, Abul K., Alam, Fazlul, and Tjarks, Werner. Wed .
"2' and 3' Carboranyl uridines and their diethyl ether adducts". United States. https://www.osti.gov/servlets/purl/868594.
@article{osti_868594,
title = {2' and 3' Carboranyl uridines and their diethyl ether adducts},
author = {Soloway, Albert H. and Barth, Rolf F. and Anisuzzaman, Abul K. and Alam, Fazlul and Tjarks, Werner},
abstractNote = {There is disclosed a process for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron containing nucleoside compounds. Said carboranyl uridine nucleoside compounds exhibit enhanced lipophilicity and hydrophilic properties adequate to enable solvation in aqueous media for subsequent incorporation of said compounds in methods for boron neutron capture therapy in mammalian tumor cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 1992},
month = {Wed Jan 01 00:00:00 EST 1992}
}
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