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Title: Boronated porphyrin compounds

Abstract

A compound is described having the structure ##STR1## where R preferably is ##STR2## and most preferably R.sup.3 is a closo-carborane and R.sup.2 is --H, an alkyl or aryl having 1 to about 7 carbon atoms, This invention was made with Government support under NIH Grant No. CA-37961 awarded by the Department of Health and Human Services and under the Associated Universities Inc. Contract No. De-AC02-76CH00016 with the U.S. Department of Energy. The Government has rights in this invention.

Inventors:
 [1];  [2]
  1. Portola Valley, CA
  2. San Francisco, CA
Issue Date:
Research Org.:
Associated Universities, Inc., Upton, NY (United States)
OSTI Identifier:
868475
Patent Number(s):
5149801
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02A - TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
boronated; porphyrin; compounds; compound; described; structure; str1; preferably; str2; closo-carborane; -h; alkyl; aryl; carbon; atoms; government; support; nih; grant; ca-37961; awarded; department; health; human; services; associated; universities; contract; de-ac02-76ch00016; energy; rights; carbon atoms; carbon atom; government support; associated universities; human services; porphyrin compounds; /999/514/

Citation Formats

Kahl, Stephen B, and Koo, Myoung-Seo. Boronated porphyrin compounds. United States: N. p., 1992. Web.
Kahl, Stephen B, & Koo, Myoung-Seo. Boronated porphyrin compounds. United States.
Kahl, Stephen B, and Koo, Myoung-Seo. Wed . "Boronated porphyrin compounds". United States. https://www.osti.gov/servlets/purl/868475.
@article{osti_868475,
title = {Boronated porphyrin compounds},
author = {Kahl, Stephen B and Koo, Myoung-Seo},
abstractNote = {A compound is described having the structure ##STR1## where R preferably is ##STR2## and most preferably R.sup.3 is a closo-carborane and R.sup.2 is --H, an alkyl or aryl having 1 to about 7 carbon atoms, This invention was made with Government support under NIH Grant No. CA-37961 awarded by the Department of Health and Human Services and under the Associated Universities Inc. Contract No. De-AC02-76CH00016 with the U.S. Department of Energy. The Government has rights in this invention.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1992},
month = {1}
}

Works referenced in this record:

Boron Neutron Capture Therapy for Cancer
journal, October 1990


Protein-binding polyhedral boranes. 1
journal, August 1974


Optimization of Boron and Neutron Delivery for Neutron Capture Therapy
journal, July 1989


Boron hydride derivatives for neutron capture therapy. Antibody approach
journal, August 1974


Preparation of carboranyl porphyrins for boron neutron capture therapy
journal, January 1990


Treatment of Malignant Melanoma by Single Thermal Neutron Capture Therapy with Melanoma-Seeking 10b-Compound
journal, August 1989


Preparation of tumor-specific boron compounds. 1. In vitro studies using boron-labeled antibodies and elemental boron as neutron targets
journal, May 1972