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Title: Chamber for the optical manipulation of microscopic particles

Abstract

A particle control chamber enables experiments to be carried out on biological cells and the like using a laser system to trap and manipulate the particles. A manipulation chamber provides a plurality of inlet and outlet ports for the particles and for fluids used to control or to contact the particles. A central manipulation area is optically accessible by the laser and includes first enlarged volumes for containing a selected number of particles for experimentation. A number of first enlarged volumes are connected by flow channels through second enlarged volumes. The second enlarged volumes act as bubble valves for controlling the interconnections between the first enlarged volumes. Electrode surfaces may be applied above the first enlarged volumes to enable experimentation using the application of electric fields within the first enlarged volumes. A variety of chemical and environmental conditions may be established within individual first enlarged volumes to enable experimental conditions for small scale cellular interactions.

Inventors:
 [1];  [1]
  1. (Los Alamos, NM)
Issue Date:
Research Org.:
Los Alamos National Laboratory (LANL), Los Alamos, NM
OSTI Identifier:
868219
Patent Number(s):
5100627
Assignee:
Regents of University of California (Oakland, CA) LANL
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
chamber; optical; manipulation; microscopic; particles; particle; control; enables; experiments; carried; biological; cells; laser; trap; manipulate; provides; plurality; inlet; outlet; ports; fluids; contact; central; optically; accessible; enlarged; volumes; containing; selected; experimentation; connected; flow; channels; bubble; valves; controlling; interconnections; electrode; surfaces; applied; enable; application; electric; fields; variety; chemical; environmental; conditions; established; individual; experimental; scale; cellular; interactions; outlet ports; chamber provides; microscopic particles; flow channels; flow channel; electric field; electrode surface; electric fields; environmental conditions; biological cells; particle control; chamber provide; scale cell; electrode surfaces; chamber enable; biological cell; /422/356/359/

Citation Formats

Buican, Tudor N., and Upham, Bryan D. Chamber for the optical manipulation of microscopic particles. United States: N. p., 1992. Web.
Buican, Tudor N., & Upham, Bryan D. Chamber for the optical manipulation of microscopic particles. United States.
Buican, Tudor N., and Upham, Bryan D. Wed . "Chamber for the optical manipulation of microscopic particles". United States. https://www.osti.gov/servlets/purl/868219.
@article{osti_868219,
title = {Chamber for the optical manipulation of microscopic particles},
author = {Buican, Tudor N. and Upham, Bryan D.},
abstractNote = {A particle control chamber enables experiments to be carried out on biological cells and the like using a laser system to trap and manipulate the particles. A manipulation chamber provides a plurality of inlet and outlet ports for the particles and for fluids used to control or to contact the particles. A central manipulation area is optically accessible by the laser and includes first enlarged volumes for containing a selected number of particles for experimentation. A number of first enlarged volumes are connected by flow channels through second enlarged volumes. The second enlarged volumes act as bubble valves for controlling the interconnections between the first enlarged volumes. Electrode surfaces may be applied above the first enlarged volumes to enable experimentation using the application of electric fields within the first enlarged volumes. A variety of chemical and environmental conditions may be established within individual first enlarged volumes to enable experimental conditions for small scale cellular interactions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1992},
month = {1}
}

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