Radiohalogenated half-antibodies and maleimide intermediate therefor
Abstract
N-(m-radiohalophenyl) maleimide can be conjugated with a reduced antibody having a mercapto group to provide a radiolabelled half-antibody having immunological specific binding characteristics of whole antibody.
- Inventors:
-
- Chestnut Hill, MA
- Newton Centre, MA
- Issue Date:
- Research Org.:
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
- OSTI Identifier:
- 867713
- Patent Number(s):
- 4994557
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- FG02-86ER60460
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- radiohalogenated; half-antibodies; maleimide; intermediate; n-; m-radiohalophenyl; conjugated; reduced; antibody; mercapto; provide; radiolabelled; half-antibody; immunological; specific; binding; characteristics; specific binding; /530/999/
Citation Formats
Kassis, Amin I, and Khawli, Leslie A. Radiohalogenated half-antibodies and maleimide intermediate therefor. United States: N. p., 1991.
Web.
Kassis, Amin I, & Khawli, Leslie A. Radiohalogenated half-antibodies and maleimide intermediate therefor. United States.
Kassis, Amin I, and Khawli, Leslie A. Tue .
"Radiohalogenated half-antibodies and maleimide intermediate therefor". United States. https://www.osti.gov/servlets/purl/867713.
@article{osti_867713,
title = {Radiohalogenated half-antibodies and maleimide intermediate therefor},
author = {Kassis, Amin I and Khawli, Leslie A},
abstractNote = {N-(m-radiohalophenyl) maleimide can be conjugated with a reduced antibody having a mercapto group to provide a radiolabelled half-antibody having immunological specific binding characteristics of whole antibody.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1991},
month = {1}
}
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