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Title: Radiohalogenated half-antibodies and maleimide intermediate therefor

Abstract

N-(m-radiohalophenyl) maleimide can be conjugated with a reduced antibody having a mercapto group to provide a radiolabelled half-antibody having immunological specific binding characteristics of whole antibody.

Inventors:
 [1];  [2]
  1. Chestnut Hill, MA
  2. Newton Centre, MA
Issue Date:
Research Org.:
Massachusetts Institute of Technology (Cambridge, MA)
OSTI Identifier:
867713
Patent Number(s):
4994557
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
DOE Contract Number:  
FG02-86ER60460
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
radiohalogenated; half-antibodies; maleimide; intermediate; n-; m-radiohalophenyl; conjugated; reduced; antibody; mercapto; provide; radiolabelled; half-antibody; immunological; specific; binding; characteristics; specific binding; /530/999/

Citation Formats

Kassis, Amin I, and Khawli, Leslie A. Radiohalogenated half-antibodies and maleimide intermediate therefor. United States: N. p., 1991. Web.
Kassis, Amin I, & Khawli, Leslie A. Radiohalogenated half-antibodies and maleimide intermediate therefor. United States.
Kassis, Amin I, and Khawli, Leslie A. Tue . "Radiohalogenated half-antibodies and maleimide intermediate therefor". United States. https://www.osti.gov/servlets/purl/867713.
@article{osti_867713,
title = {Radiohalogenated half-antibodies and maleimide intermediate therefor},
author = {Kassis, Amin I and Khawli, Leslie A},
abstractNote = {N-(m-radiohalophenyl) maleimide can be conjugated with a reduced antibody having a mercapto group to provide a radiolabelled half-antibody having immunological specific binding characteristics of whole antibody.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1991},
month = {1}
}

Patent:

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