Antithrombogenic and antibiotic composition and methods of preparation thereof

Hermes, Robert E

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Title: Antithrombogenic and antibiotic composition and methods of preparation thereof

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Abstract

Antithrombogenic and antibiotic composition of matter and method of preparation thereof. A random copolymer of a component of garlic and a biocompatible polymer has been prepared and found to exhibit antithrombogenic and antibiotic properties. Polymerization occurs selectively at the vinyl moiety in 2-vinyl-4H-1,3-dithiin when copolymerized with N-vinyl pyrrolidone.

Inventors:

Hermes, Robert E ^[1]

Los Alamos, NM

Issue Date:: 1990-01-01

Research Org.:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

OSTI Identifier:: 867345

Patent Number(s):: 4917921

Assignee:: United States of America as represented by United States (Washington, DC)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/74 - Synthetic polymeric materials
A61K31/795 - Polymers containing sulfur

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
A61L2300/406 - Antibiotics
A61L2300/42 - Anti-thrombotic agents, anticoagulants, anti-platelet agents
A61L27/34 - Macromolecular materials
A61L27/54 - Biologically active materials, e.g. therapeutic substances {
A61L33/0088 - {by grafting of a monomer onto the substrate}
A61L33/064 - {obtained by reactions only involving carbon-to-carbon unsaturated bonds

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/04 - Antibacterial agents
A61P7/02 - Antithrombotic agents

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
C08F228/06 - by a heterocyclic ring containing sulfur

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
C08L41/00 - Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a bond to sulfur or by a heterocyclic ring containing sulfur
C08L51/06 - grafted on to homopolymers or copolymers of aliphatic hydrocarbons containing only one carbon-to-carbon double bond

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DOE Contract Number:: W-7405-ENG-36

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: antithrombogenic; antibiotic; composition; methods; preparation; matter; method; random; copolymer; component; garlic; biocompatible; polymer; prepared; found; exhibit; properties; polymerization; occurs; selectively; vinyl; moiety; 2-vinyl-4h-1; 3-dithiin; copolymerized; n-vinyl; pyrrolidone; random copolymer; antibiotic composition; /427/522/526/

Citation Formats


                    Hermes, Robert E. Antithrombogenic and antibiotic composition and methods of preparation thereof.  United States: N. p., 1990. 
        Web.

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                    Hermes, Robert E. Antithrombogenic and antibiotic composition and methods of preparation thereof.  United States.

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                    Hermes, Robert E. Mon .  
        "Antithrombogenic and antibiotic composition and methods of preparation thereof".  United States.  https://www.osti.gov/servlets/purl/867345.

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@article{osti_867345,

  title        = {Antithrombogenic and antibiotic composition and methods of preparation thereof},

  author       = {Hermes, Robert E},

  abstractNote = {Antithrombogenic and antibiotic composition of matter and method of preparation thereof. A random copolymer of a component of garlic and a biocompatible polymer has been prepared and found to exhibit antithrombogenic and antibiotic properties. Polymerization occurs selectively at the vinyl moiety in 2-vinyl-4H-1,3-dithiin when copolymerized with N-vinyl pyrrolidone.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1990},

  month        = {1}

}

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Antithrombogenic and antibiotic compositions and methods of preparation thereof

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Antithrombogenic and antibiotic composition of matter and method of preparation thereof. A random copolymer of a component of garlic and a biocompatible polymer has been prepared and found to exhibit antithrombogenic and antibiotic properties. Polymerization occurs selectively at the vinyl moiety in 2-vinyl-4H-1,3-dithiin when copolymerized with N-vinyl pyrrolidone. 4 figs., 2 tabs.
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