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Title: Aminopropyl thiophene compounds

Abstract

Radiopharmaceuticals useful in brain imaging comprising radiohalogenated thienylethylamine derivatives. The compounds are 5-halo-thiophene-2-isopropyl amines able to cross the blood-brain barrier and be retained for a sufficient length of time to allow the evaluation of regional blood flow by radioimaging of the brain.

Inventors:
 [1];  [2]
  1. Knoxville, TN
  2. (Oak Ridge, TN)
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
OSTI Identifier:
867325
Patent Number(s):
4914215
Assignee:
United States of America as represented by United States (Washington, DC)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
aminopropyl; thiophene; compounds; radiopharmaceuticals; useful; brain; imaging; comprising; radiohalogenated; thienylethylamine; derivatives; 5-halo-thiophene-2-isopropyl; amines; blood-brain; barrier; retained; sufficient; length; time; allow; evaluation; regional; blood; flow; radioimaging; blood flow; sufficient length; radiohalogenated thienylethylamine; thienylethylamine derivatives; radiopharmaceuticals useful; comprising radiohalogenated; imaging comprising; brain imaging; blood-brain barrier; /999/

Citation Formats

Goodman, Mark M, and Knapp, Jr., Furn F. Aminopropyl thiophene compounds. United States: N. p., 1990. Web.
Goodman, Mark M, & Knapp, Jr., Furn F. Aminopropyl thiophene compounds. United States.
Goodman, Mark M, and Knapp, Jr., Furn F. Mon . "Aminopropyl thiophene compounds". United States. https://www.osti.gov/servlets/purl/867325.
@article{osti_867325,
title = {Aminopropyl thiophene compounds},
author = {Goodman, Mark M and Knapp, Jr., Furn F.},
abstractNote = {Radiopharmaceuticals useful in brain imaging comprising radiohalogenated thienylethylamine derivatives. The compounds are 5-halo-thiophene-2-isopropyl amines able to cross the blood-brain barrier and be retained for a sufficient length of time to allow the evaluation of regional blood flow by radioimaging of the brain.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1990},
month = {1}
}

Patent:

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