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Title: Multiplexed electronically programmable multimode ionization detector for chromatography

Abstract

Method and apparatus for detecting and differentiating organic compounds based on their electron affinity. An electron capture detector cell (ECD) is operated in a plurality of multiplexed electroncially programmable operating modes to alter the detector response during a single sampling cycle to acquire multiple simultaneous chromatograms corresponding to each of the different operating modes. The cell is held at a constant subatmospheric pressure while the electron collection bias voltage applied to the cell is modulated electronically to allow acquisition of multiple chromatograms for a single sample elution from a chromatograph representing three distinctly different response modes. A system is provided which automatically controls the programmed application of bias pulses at different intervals and/or amplitudes to switch the detector from an ionization mode to the electron capture mode and various degrees therebetween to provide an improved means of tuning an ECD for multimode detection and improved specificity.

Inventors:
 [1];  [2]
  1. (Kingston, TN)
  2. (Knoxville, TN)
Issue Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN
OSTI Identifier:
867168
Patent Number(s):
4879472
Assignee:
United States of America as represented by United States (Washington, DC) ORNL
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
multiplexed; electronically; programmable; multimode; ionization; detector; chromatography; method; apparatus; detecting; differentiating; organic; compounds; based; electron; affinity; capture; cell; ecd; operated; plurality; electroncially; operating; modes; alter; response; single; sampling; cycle; acquire; multiple; simultaneous; chromatograms; corresponding; held; constant; subatmospheric; pressure; collection; bias; voltage; applied; modulated; allow; acquisition; sample; elution; chromatograph; representing; distinctly; provided; automatically; controls; programmed; application; pulses; intervals; amplitudes; switch; mode; various; degrees; therebetween; provide; improved; means; tuning; detection; specificity; voltage applied; organic compound; organic compounds; atmospheric pressure; bias voltage; ionization detector; subatmospheric pressure; electron affinity; electron capture; automatically control; modulated electron; operating modes; modulated electronic; detector cell; ionization mode; compounds based; operating mode; capture detector; differentiating organic; /250/

Citation Formats

Wise, Marcus B., and Buchanan, Michelle V. Multiplexed electronically programmable multimode ionization detector for chromatography. United States: N. p., 1989. Web.
Wise, Marcus B., & Buchanan, Michelle V. Multiplexed electronically programmable multimode ionization detector for chromatography. United States.
Wise, Marcus B., and Buchanan, Michelle V. Sun . "Multiplexed electronically programmable multimode ionization detector for chromatography". United States. https://www.osti.gov/servlets/purl/867168.
@article{osti_867168,
title = {Multiplexed electronically programmable multimode ionization detector for chromatography},
author = {Wise, Marcus B. and Buchanan, Michelle V.},
abstractNote = {Method and apparatus for detecting and differentiating organic compounds based on their electron affinity. An electron capture detector cell (ECD) is operated in a plurality of multiplexed electroncially programmable operating modes to alter the detector response during a single sampling cycle to acquire multiple simultaneous chromatograms corresponding to each of the different operating modes. The cell is held at a constant subatmospheric pressure while the electron collection bias voltage applied to the cell is modulated electronically to allow acquisition of multiple chromatograms for a single sample elution from a chromatograph representing three distinctly different response modes. A system is provided which automatically controls the programmed application of bias pulses at different intervals and/or amplitudes to switch the detector from an ionization mode to the electron capture mode and various degrees therebetween to provide an improved means of tuning an ECD for multimode detection and improved specificity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1989},
month = {1}
}

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