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Title: Controlled release liquid dosage formulation

Abstract

A liquid dual coated dosage formulation sustained release pharmaceutic having substantial shelf life prior to ingestion is disclosed. A dual coating is applied over controlled release cores to form dosage forms and the coatings comprise fats melting at less than approximately 101.degree. F. overcoated with cellulose acetate phthalate or zein. The dual coated dosage forms are dispersed in a sugar based acidic liquid carrier such as high fructose corn syrup and display a shelf life of up to approximately at least 45 days while still retaining their release profiles following ingestion. Cellulose acetate phthalate coated dosage form cores can in addition be dispersed in aqueous liquids of pH <5.

Inventors:
 [1];  [2]
  1. (Centerburg, OH)
  2. (Bellville, OH)
Issue Date:
Research Org.:
BATTELLE MEMORIAL INSTITUTE
OSTI Identifier:
867151
Patent Number(s):
4876094
Assignee:
Battelle Development Corporation (Columbus, OH) PNNL
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
controlled; release; liquid; dosage; formulation; dual; coated; sustained; pharmaceutic; substantial; shelf; life; prior; ingestion; disclosed; coating; applied; cores; form; forms; coatings; comprise; fats; melting; approximately; 101; degree; overcoated; cellulose; acetate; phthalate; zein; dispersed; sugar; based; acidic; carrier; fructose; corn; syrup; display; 45; days; retaining; profiles; following; addition; aqueous; liquids; ph; aqueous liquid; cellulose acetate; controlled release; liquid carrier; shelf life; aqueous liquids; release liquid; acetate ph; dosage formulation; /424/426/

Citation Formats

Benton, Ben F., and Gardner, David L. Controlled release liquid dosage formulation. United States: N. p., 1989. Web.
Benton, Ben F., & Gardner, David L. Controlled release liquid dosage formulation. United States.
Benton, Ben F., and Gardner, David L. Sun . "Controlled release liquid dosage formulation". United States. https://www.osti.gov/servlets/purl/867151.
@article{osti_867151,
title = {Controlled release liquid dosage formulation},
author = {Benton, Ben F. and Gardner, David L.},
abstractNote = {A liquid dual coated dosage formulation sustained release pharmaceutic having substantial shelf life prior to ingestion is disclosed. A dual coating is applied over controlled release cores to form dosage forms and the coatings comprise fats melting at less than approximately 101.degree. F. overcoated with cellulose acetate phthalate or zein. The dual coated dosage forms are dispersed in a sugar based acidic liquid carrier such as high fructose corn syrup and display a shelf life of up to approximately at least 45 days while still retaining their release profiles following ingestion. Cellulose acetate phthalate coated dosage form cores can in addition be dispersed in aqueous liquids of pH <5.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1989},
month = {1}
}

Patent:

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