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Title: Device and method for automated separation of a sample of whole blood into aliquots

Abstract

A device and a method for automated processing and separation of an unmeasured sample of whole blood into multiple aliquots of plasma. Capillaries are radially oriented on a rotor, with the rotor defining a sample chamber, transfer channels, overflow chamber, overflow channel, vent channel, cell chambers, and processing chambers. A sample of whole blood is placed in the sample chamber, and when the rotor is rotated, the blood moves outward through the transfer channels to the processing chambers where the blood is centrifugally separated into a solid cellular component and a liquid plasma component. When the rotor speed is decreased, the plasma component backfills the capillaries resulting in uniform aliquots of plasma which may be used for subsequent analytical procedures.

Inventors:
 [1];  [2]
  1. (Oak Ridge, TN)
  2. (Loudon, TN)
Issue Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN
OSTI Identifier:
867032
Patent Number(s):
4847205
Assignee:
Martin Marietta Energy Systems, Inc. (Oak Ridge, TN) ORNL
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
device; method; automated; separation; sample; blood; aliquots; processing; unmeasured; multiple; plasma; capillaries; radially; oriented; rotor; defining; chamber; transfer; channels; overflow; channel; cell; chambers; placed; rotated; moves; outward; centrifugally; separated; solid; cellular; component; liquid; speed; decreased; backfills; resulting; uniform; subsequent; analytical; procedures; sample chamber; processing chamber; flow channel; flow chamber; automated process; cell chamber; rotor speed; cellular component; automated processing; automated separation; /436/422/494/

Citation Formats

Burtis, Carl A., and Johnson, Wayne F. Device and method for automated separation of a sample of whole blood into aliquots. United States: N. p., 1989. Web.
Burtis, Carl A., & Johnson, Wayne F. Device and method for automated separation of a sample of whole blood into aliquots. United States.
Burtis, Carl A., and Johnson, Wayne F. Sun . "Device and method for automated separation of a sample of whole blood into aliquots". United States. https://www.osti.gov/servlets/purl/867032.
@article{osti_867032,
title = {Device and method for automated separation of a sample of whole blood into aliquots},
author = {Burtis, Carl A. and Johnson, Wayne F.},
abstractNote = {A device and a method for automated processing and separation of an unmeasured sample of whole blood into multiple aliquots of plasma. Capillaries are radially oriented on a rotor, with the rotor defining a sample chamber, transfer channels, overflow chamber, overflow channel, vent channel, cell chambers, and processing chambers. A sample of whole blood is placed in the sample chamber, and when the rotor is rotated, the blood moves outward through the transfer channels to the processing chambers where the blood is centrifugally separated into a solid cellular component and a liquid plasma component. When the rotor speed is decreased, the plasma component backfills the capillaries resulting in uniform aliquots of plasma which may be used for subsequent analytical procedures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1989},
month = {1}
}

Patent:

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