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Title: Method and apparatus for diagnosis of lead toxicity

Abstract

Improved methods and apparatus for in vivo measurement of the skeletal lead burden of a patient and for diagnosis of lead toxicity are disclosed. The apparatus comprises an x-ray tube emitting soft low energy x-rays from a silver anode, a polarizer for polarizing the emitted x-rays, and a detector for detecting photons fluoresced from atoms in the patient's tibia upon irradiation by the polarized x-rays. The fluoresced photons are spectrally analyzed to determine their energy distribution. Peaks indicating the presence of lead are identified if the patient has relatively high bone lead content. The data may be compared to data recorded with respect to a similar test performed on patients having also had the conventional EDTA chelation tests performed thereon in order to correlate the test results with respect to a particular patient to the conventionally accepted EDTA chelation test.

Inventors:
 [1];  [2];  [3]
  1. Riverside, CT
  2. Bayside, NY
  3. Shirley, NY
Issue Date:
OSTI Identifier:
867026
Patent Number(s):
4845729
Assignee:
Elex Analytical Technologies Corp. (Upton, NY)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; apparatus; diagnosis; lead; toxicity; improved; methods; vivo; measurement; skeletal; burden; patient; disclosed; comprises; x-ray; tube; emitting; soft; energy; x-rays; silver; anode; polarizer; polarizing; emitted; detector; detecting; photons; fluoresced; atoms; tibia; irradiation; polarized; spectrally; analyzed; determine; distribution; peaks; indicating; presence; identified; relatively; bone; content; data; compared; recorded; respect; similar; performed; patients; conventional; edta; chelation; tests; thereon; correlate; results; particular; conventionally; accepted; ray tube; improved method; apparatus comprises; energy distribution; x-ray tube; formed thereon; apparatus comprise; energy x-rays; improved methods; lead content; vivo measurement; lead toxicity; /378/

Citation Formats

Rosen, John F, Slatkin, Daniel N, and Wielopolski, Lucian. Method and apparatus for diagnosis of lead toxicity. United States: N. p., 1989. Web.
Rosen, John F, Slatkin, Daniel N, & Wielopolski, Lucian. Method and apparatus for diagnosis of lead toxicity. United States.
Rosen, John F, Slatkin, Daniel N, and Wielopolski, Lucian. Sun . "Method and apparatus for diagnosis of lead toxicity". United States. https://www.osti.gov/servlets/purl/867026.
@article{osti_867026,
title = {Method and apparatus for diagnosis of lead toxicity},
author = {Rosen, John F and Slatkin, Daniel N and Wielopolski, Lucian},
abstractNote = {Improved methods and apparatus for in vivo measurement of the skeletal lead burden of a patient and for diagnosis of lead toxicity are disclosed. The apparatus comprises an x-ray tube emitting soft low energy x-rays from a silver anode, a polarizer for polarizing the emitted x-rays, and a detector for detecting photons fluoresced from atoms in the patient's tibia upon irradiation by the polarized x-rays. The fluoresced photons are spectrally analyzed to determine their energy distribution. Peaks indicating the presence of lead are identified if the patient has relatively high bone lead content. The data may be compared to data recorded with respect to a similar test performed on patients having also had the conventional EDTA chelation tests performed thereon in order to correlate the test results with respect to a particular patient to the conventionally accepted EDTA chelation test.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1989},
month = {1}
}