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Title: Method for preparing radiopharmaceutical complexes

Abstract

A method for preparing radiopharmaceutical complexes that are substantially free of the reaction materials used to produce the radiopharmaceutical complex is disclosed. The method involves admixing in a suitable first solvent in a container a target seeking ligand or salt or metal adduct thereof, a radionuclide label, and a reducing agent for said radionuclide, thereby forming said radiopharmaceutical complex; coating the interior walls of the container with said pharmaceutical complex; discarding the solvent containing by-products and unreacted starting reaction materials; and removing the radiopharmaceutical complex from said walls by dissolving it in a second solvent, thereby obtaining said radiopharmaceutical complex substantially free of by-products and unreacted starting materials.

Inventors:
 [1];  [2];  [3]
  1. (Newton Centre, MA)
  2. (Needham, MA)
  3. (Westchester, PA)
Issue Date:
Research Org.:
MASSACHUSETTS INST OF TECH
OSTI Identifier:
866940
Patent Number(s):
4826961
Application Number:
07/006,562
Assignee:
President and Fellows of Harvard College (Cambridge, MA); Massachusetts Institute of Technology (Cambridge, MA) OSTI
DOE Contract Number:  
AC02-76EV04115
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; preparing; radiopharmaceutical; complexes; substantially; free; reaction; materials; produce; complex; disclosed; involves; admixing; suitable; solvent; container; target; seeking; ligand; salt; metal; adduct; radionuclide; label; reducing; agent; forming; coating; interior; walls; pharmaceutical; discarding; containing; by-products; unreacted; starting; removing; dissolving; obtaining; interior walls; interior wall; solvent containing; starting material; substantially free; method involves; reducing agent; starting materials; reaction materials; radiopharmaceutical complex; radiopharmaceutical complexes; method involve; pharmaceutical complex; radionuclide label; reaction material; preparing radiopharmaceutical; /999/252/987/

Citation Formats

Jones, Alun G., Davison, Alan, and Abrams, Michael J. Method for preparing radiopharmaceutical complexes. United States: N. p., 1989. Web.
Jones, Alun G., Davison, Alan, & Abrams, Michael J. Method for preparing radiopharmaceutical complexes. United States.
Jones, Alun G., Davison, Alan, and Abrams, Michael J. Tue . "Method for preparing radiopharmaceutical complexes". United States. https://www.osti.gov/servlets/purl/866940.
@article{osti_866940,
title = {Method for preparing radiopharmaceutical complexes},
author = {Jones, Alun G. and Davison, Alan and Abrams, Michael J.},
abstractNote = {A method for preparing radiopharmaceutical complexes that are substantially free of the reaction materials used to produce the radiopharmaceutical complex is disclosed. The method involves admixing in a suitable first solvent in a container a target seeking ligand or salt or metal adduct thereof, a radionuclide label, and a reducing agent for said radionuclide, thereby forming said radiopharmaceutical complex; coating the interior walls of the container with said pharmaceutical complex; discarding the solvent containing by-products and unreacted starting reaction materials; and removing the radiopharmaceutical complex from said walls by dissolving it in a second solvent, thereby obtaining said radiopharmaceutical complex substantially free of by-products and unreacted starting materials.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1989},
month = {5}
}

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