Method for preparing radiopharmaceutical complexes

Jones, Alun G; Davison, Alan; Abrams, Michael J

Title: Method for preparing radiopharmaceutical complexes

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Abstract

A method for preparing radiopharmaceutical complexes that are substantially free of the reaction materials used to produce the radiopharmaceutical complex is disclosed. The method involves admixing in a suitable first solvent in a container a target seeking ligand or salt or metal adduct thereof, a radionuclide label, and a reducing agent for said radionuclide, thereby forming said radiopharmaceutical complex; coating the interior walls of the container with said pharmaceutical complex; discarding the solvent containing by-products and unreacted starting reaction materials; and removing the radiopharmaceutical complex from said walls by dissolving it in a second solvent, thereby obtaining said radiopharmaceutical complex substantially free of by-products and unreacted starting materials.

Inventors:

Jones, Alun G ^[1]; Davison, Alan ^[2]; Abrams, Michael J ^[3]

Newton Centre, MA
Needham, MA
Westchester, PA

Issue Date:: 1989-05-02

Research Org.:: Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

OSTI Identifier:: 866940

Patent Number(s):: 4826961

Application Number:: 07/006,562

Assignee:: President and Fellows of Harvard College (Cambridge, MA); Massachusetts Institute of Technology (Cambridge, MA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2123/00 - Preparations for testing in vivo

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F3/06 - Zinc compounds

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K51/0476 - {complexes from monodendate ligands, e.g. sestamibi}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F13/00 - Compounds containing elements of Groups 7 or 17 of the Periodic System

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DOE Contract Number:: AC02-76EV04115

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: method; preparing; radiopharmaceutical; complexes; substantially; free; reaction; materials; produce; complex; disclosed; involves; admixing; suitable; solvent; container; target; seeking; ligand; salt; metal; adduct; radionuclide; label; reducing; agent; forming; coating; interior; walls; pharmaceutical; discarding; containing; by-products; unreacted; starting; removing; dissolving; obtaining; interior walls; interior wall; solvent containing; starting material; substantially free; method involves; reducing agent; starting materials; reaction materials; radiopharmaceutical complex; radiopharmaceutical complexes; method involve; pharmaceutical complex; radionuclide label; reaction material; preparing radiopharmaceutical; /999/252/987/

Citation Formats


                    Jones, Alun G, Davison, Alan, and Abrams, Michael J. Method for preparing radiopharmaceutical complexes.  United States: N. p., 1989. 
        Web.

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                    Jones, Alun G, Davison, Alan, & Abrams, Michael J. Method for preparing radiopharmaceutical complexes.  United States.

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                    Jones, Alun G, Davison, Alan, and Abrams, Michael J. Tue .  
        "Method for preparing radiopharmaceutical complexes".  United States.  https://www.osti.gov/servlets/purl/866940.

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@article{osti_866940,

  title        = {Method for preparing radiopharmaceutical complexes},

  author       = {Jones, Alun G and Davison, Alan and Abrams, Michael J},

  abstractNote = {A method for preparing radiopharmaceutical complexes that are substantially free of the reaction materials used to produce the radiopharmaceutical complex is disclosed. The method involves admixing in a suitable first solvent in a container a target seeking ligand or salt or metal adduct thereof, a radionuclide label, and a reducing agent for said radionuclide, thereby forming said radiopharmaceutical complex; coating the interior walls of the container with said pharmaceutical complex; discarding the solvent containing by-products and unreacted starting reaction materials; and removing the radiopharmaceutical complex from said walls by dissolving it in a second solvent, thereby obtaining said radiopharmaceutical complex substantially free of by-products and unreacted starting materials.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1989},

  month        = {5}

}

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