Enzymatic temperature change indicator
Abstract
A temperature change indicator is described which is composed of an enzyme and a substrate for that enzyme suspended in a solid organic solvent or mixture of solvents as a support medium. The organic solvent or solvents are chosen so as to melt at a specific temperature or in a specific temperature range. When the temperature of the indicator is elevated above the chosen, or critical temperature, the solid organic solvent support will melt, and the enzymatic reaction will occur, producing a visually detectable product which is stable to further temperature variation.
- Inventors:
-
- Newton, MA
- Iowa City, IA
- Issue Date:
- Research Org.:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 866939
- Patent Number(s):
- 4826762
- Application Number:
- 06/459,787
- Assignee:
- Massachusetts Industry of Technology (Cambridge, MA)
- Patent Classifications (CPCs):
-
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
G - PHYSICS G01 - MEASURING G01K - MEASURING TEMPERATURE
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- enzymatic; temperature; change; indicator; described; composed; enzyme; substrate; suspended; solid; organic; solvent; mixture; solvents; support; medium; chosen; melt; specific; range; elevated; critical; reaction; occur; producing; visually; detectable; product; stable; variation; enzymatic reaction; temperature change; solid organic; critical temperature; temperature range; organic solvent; temperature variation; change indicator; support medium; /435/116/374/426/
Citation Formats
Klibanov, Alexander M, and Dordick, Jonathan S. Enzymatic temperature change indicator. United States: N. p., 1989.
Web.
Klibanov, Alexander M, & Dordick, Jonathan S. Enzymatic temperature change indicator. United States.
Klibanov, Alexander M, and Dordick, Jonathan S. Sat .
"Enzymatic temperature change indicator". United States. https://www.osti.gov/servlets/purl/866939.
@article{osti_866939,
title = {Enzymatic temperature change indicator},
author = {Klibanov, Alexander M and Dordick, Jonathan S},
abstractNote = {A temperature change indicator is described which is composed of an enzyme and a substrate for that enzyme suspended in a solid organic solvent or mixture of solvents as a support medium. The organic solvent or solvents are chosen so as to melt at a specific temperature or in a specific temperature range. When the temperature of the indicator is elevated above the chosen, or critical temperature, the solid organic solvent support will melt, and the enzymatic reaction will occur, producing a visually detectable product which is stable to further temperature variation.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1989},
month = {1}
}