Enzymatic temperature change indicator

Title: Enzymatic temperature change indicator

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Abstract

A temperature change indicator is described which is composed of an enzyme and a substrate for that enzyme suspended in a solid organic solvent or mixture of solvents as a support medium. The organic solvent or solvents are chosen so as to melt at a specific temperature or in a specific temperature range. When the temperature of the indicator is elevated above the chosen, or critical temperature, the solid organic solvent support will melt, and the enzymatic reaction will occur, producing a visually detectable product which is stable to further temperature variation.

Inventors:

Klibanov, Alexander M ^[1]; Dordick, Jonathan S ^[2]

Newton, MA
Iowa City, IA

Issue Date:: 1989-01-21

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:: 866939

Patent Number(s):: 4826762

Application Number:: 06/459,787

Assignee:: Massachusetts Industry of Technology (Cambridge, MA)

Patent Classifications (CPCs):: Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

G - PHYSICS G01 - MEASURING G01K - MEASURING TEMPERATURE

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Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S435/81 - Packaged device or kit

G - PHYSICS G01 - MEASURING G01K - MEASURING TEMPERATURE
G01K11/06 - using melting, freezing, or softening

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N31/229 - {for investigating time/temperature history}

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/28 - involving peroxidase

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Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: enzymatic; temperature; change; indicator; described; composed; enzyme; substrate; suspended; solid; organic; solvent; mixture; solvents; support; medium; chosen; melt; specific; range; elevated; critical; reaction; occur; producing; visually; detectable; product; stable; variation; enzymatic reaction; temperature change; solid organic; critical temperature; temperature range; organic solvent; temperature variation; change indicator; support medium; /435/116/374/426/

Citation Formats


                    Klibanov, Alexander M, and Dordick, Jonathan S. Enzymatic temperature change indicator.  United States: N. p., 1989. 
        Web.

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                    Klibanov, Alexander M, & Dordick, Jonathan S. Enzymatic temperature change indicator.  United States.

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                    Klibanov, Alexander M, and Dordick, Jonathan S. Sat .  
        "Enzymatic temperature change indicator".  United States.  https://www.osti.gov/servlets/purl/866939.

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@article{osti_866939,

  title        = {Enzymatic temperature change indicator},

  author       = {Klibanov, Alexander M and Dordick, Jonathan S},

  abstractNote = {A temperature change indicator is described which is composed of an enzyme and a substrate for that enzyme suspended in a solid organic solvent or mixture of solvents as a support medium. The organic solvent or solvents are chosen so as to melt at a specific temperature or in a specific temperature range. When the temperature of the indicator is elevated above the chosen, or critical temperature, the solid organic solvent support will melt, and the enzymatic reaction will occur, producing a visually detectable product which is stable to further temperature variation.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1989},

  month        = {1}

}

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