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Title: Continuous human cell lines and method of making same

Abstract

Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo[a]pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors.

Inventors:
 [1]
  1. (Oakland, CA)
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
OSTI Identifier:
866860
Patent Number(s):
4808532
Assignee:
United States of America as represented by United States (Washington, DC) LBNL
DOE Contract Number:  
AP03-84SF15389
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
continuous; human; cell; lines; method; substantially; genetically; stable; derived; normal; mammary; epithelial; cells; hmec; processes; preferred; embodiment; treating; tissue; chemical; carcinogen; benzo; pyrene; novel; serve; useful; substrates; elucidating; potential; effects; toxins; carcinogens; mutagens; addition; exogenous; genetic; material; autogenic; parent; convenient; control; samples; testing; neoplastically; transformed; acquired; properties; distinguish; progenitors; genetic material; cell lines; preferred embodiment; normal human; epithelial cells; human mammary; mammary epithelial; cell line; human cell; continuous human; /435/

Citation Formats

Stampfer, Martha R. Continuous human cell lines and method of making same. United States: N. p., 1989. Web.
Stampfer, Martha R. Continuous human cell lines and method of making same. United States.
Stampfer, Martha R. Sun . "Continuous human cell lines and method of making same". United States. https://www.osti.gov/servlets/purl/866860.
@article{osti_866860,
title = {Continuous human cell lines and method of making same},
author = {Stampfer, Martha R.},
abstractNote = {Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo[a]pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1989},
month = {1}
}

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