Precursors to radiopharmaceutical agents for tissue imaging
Abstract
A class of radiolabeled compounds to be used in tissue imaging that exhibits rapid brain uptake, good brain:blood radioactivity ratios, and long retention times. The imaging agents are more specifically radioiodinated aromatic amines attached to dihydropyridine carriers, that exhibit heart as well as brain specificity. In addition to the radiolabeled compounds, classes of compounds are also described that are used as precursors and intermediates in the preparation of the imaging agents.
- Inventors:
-
- Oak Ridge, TN
- (Oak Ridge, TN)
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 866689
- Patent Number(s):
- 4764598
- Assignee:
- United States of America as represented by Department of Energy (Washington, DC)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- W-7405-ENG-26
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- precursors; radiopharmaceutical; agents; tissue; imaging; radiolabeled; compounds; exhibits; rapid; brain; uptake; blood; radioactivity; ratios; retention; times; specifically; radioiodinated; aromatic; amines; attached; dihydropyridine; carriers; exhibit; heart; specificity; addition; described; intermediates; preparation; aromatic amines; imaging agents; labeled compounds; retention time; imaging agent; tissue imaging; rapid brain; radiolabeled compound; aromatic amine; /999/
Citation Formats
Srivastava, Prem C, and Knapp, Jr., Furn F. Precursors to radiopharmaceutical agents for tissue imaging. United States: N. p., 1988.
Web.
Srivastava, Prem C, & Knapp, Jr., Furn F. Precursors to radiopharmaceutical agents for tissue imaging. United States.
Srivastava, Prem C, and Knapp, Jr., Furn F. Fri .
"Precursors to radiopharmaceutical agents for tissue imaging". United States. https://www.osti.gov/servlets/purl/866689.
@article{osti_866689,
title = {Precursors to radiopharmaceutical agents for tissue imaging},
author = {Srivastava, Prem C and Knapp, Jr., Furn F.},
abstractNote = {A class of radiolabeled compounds to be used in tissue imaging that exhibits rapid brain uptake, good brain:blood radioactivity ratios, and long retention times. The imaging agents are more specifically radioiodinated aromatic amines attached to dihydropyridine carriers, that exhibit heart as well as brain specificity. In addition to the radiolabeled compounds, classes of compounds are also described that are used as precursors and intermediates in the preparation of the imaging agents.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1988},
month = {1}
}
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