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Title: Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer

Abstract

A rotor and disc assembly for use in a centrifugal fast analyzer. The assembly is designed to process multiple samples of whole blood followed by aliquoting of the resultant serum into precisely measured samples for subsequent chemical analysis. The assembly requires minimal operator involvement with no mechanical pipetting. The system comprises (1) a whole blood sample disc, (2) a serum sample disc, (3) a sample preparation rotor, and (4) an analytical rotor. The blood sample disc and serum sample disc are designed with a plurality of precision bore capillary tubes arranged in a spoked array. Samples of blood are loaded into the blood sample disc in capillary tubes filled by capillary action and centrifugally discharged into cavities of the sample preparation rotor where separation of serum and solids is accomplished. The serum is loaded into the capillaries of the serum sample disc by capillary action and subsequently centrifugally expelled into cuvettes of the analytical rotor for analysis by conventional methods.

Inventors:
 [1];  [2];  [3]
  1. Oak Ridge, TN
  2. Loudon, TN
  3. Knoxville, TN
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
OSTI Identifier:
866572
Patent Number(s):
4740472
Assignee:
United States of America as represented by United States (Washington, DC)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; apparatus; automated; processing; aliquoting; blood; samples; analysis; centrifugal; fast; analyzer; rotor; disc; assembly; designed; process; multiple; followed; resultant; serum; precisely; measured; subsequent; chemical; requires; minimal; operator; involvement; mechanical; pipetting; comprises; sample; preparation; analytical; plurality; precision; bore; capillary; tubes; arranged; spoked; array; loaded; filled; action; centrifugally; discharged; cavities; separation; solids; accomplished; capillaries; subsequently; expelled; cuvettes; conventional; methods; capillary tubes; blood sample; blood samples; fast analyzer; chemical analysis; sample preparation; conventional methods; capillary tube; capillary action; automated process; multiple samples; bore capillary; centrifugal fast; subsequent chemical; multiple sample; automated processing; disc assembly; /436/210/422/494/

Citation Formats

Burtis, Carl A, Johnson, Wayne F, and Walker, William A. Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer. United States: N. p., 1988. Web.
Burtis, Carl A, Johnson, Wayne F, & Walker, William A. Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer. United States.
Burtis, Carl A, Johnson, Wayne F, and Walker, William A. Fri . "Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer". United States. https://www.osti.gov/servlets/purl/866572.
@article{osti_866572,
title = {Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer},
author = {Burtis, Carl A and Johnson, Wayne F and Walker, William A},
abstractNote = {A rotor and disc assembly for use in a centrifugal fast analyzer. The assembly is designed to process multiple samples of whole blood followed by aliquoting of the resultant serum into precisely measured samples for subsequent chemical analysis. The assembly requires minimal operator involvement with no mechanical pipetting. The system comprises (1) a whole blood sample disc, (2) a serum sample disc, (3) a sample preparation rotor, and (4) an analytical rotor. The blood sample disc and serum sample disc are designed with a plurality of precision bore capillary tubes arranged in a spoked array. Samples of blood are loaded into the blood sample disc in capillary tubes filled by capillary action and centrifugally discharged into cavities of the sample preparation rotor where separation of serum and solids is accomplished. The serum is loaded into the capillaries of the serum sample disc by capillary action and subsequently centrifugally expelled into cuvettes of the analytical rotor for analysis by conventional methods.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1988},
month = {1}
}

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