Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes
Abstract
A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula: (CNX)R, where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same or different is disclosed. Kits that can be used to form these complexes are also disclosed.
- Inventors:
-
- Newton Centre, MA
- Needham, MA
- Cambridge, MA
- Allston, MA
- Issue Date:
- Research Org.:
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
- OSTI Identifier:
- 866559
- Patent Number(s):
- 4735793
- Application Number:
- 06/771,284
- Assignee:
- Massachusetts Institute of Technology (Cambridge, MA); President and Fellows of Harvard College (Cambridge, MA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- DOE Contract Number:
- AC02-76EV04115
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- carboxy; carboalkoxy; carbamile; substituted; isonitrile; radionuclide; complexes; coordination; complex; comprising; selected; consisting; radioactive; isotopes; tc; ru; ligand; formula; cnx; alkyl; carbon; atoms; coor; conr; pharmaceutically; acceptable; cation; unsubstituted; disclosed; kits; form; unsubstituted alkyl; radionuclide complexes; radioactive isotope; isonitrile ligand; carbon atoms; carbon atom; pharmaceutically acceptable; isonitrile radionuclide; radioactive isotopes; coordination complex; radionuclide selected; substituted isonitrile; complex comprising; substituted alkyl; carbamile substituted; /424/999/987/
Citation Formats
Jones, Alun G, Davison, Alan, Kronauge, James, and Abrams, Michael J. Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes. United States: N. p., 1988.
Web.
Jones, Alun G, Davison, Alan, Kronauge, James, & Abrams, Michael J. Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes. United States.
Jones, Alun G, Davison, Alan, Kronauge, James, and Abrams, Michael J. Tue .
"Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes". United States. https://www.osti.gov/servlets/purl/866559.
@article{osti_866559,
title = {Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes},
author = {Jones, Alun G and Davison, Alan and Kronauge, James and Abrams, Michael J},
abstractNote = {A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula: (CNX)R, where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same or different is disclosed. Kits that can be used to form these complexes are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1988},
month = {4}
}
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