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Title: Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes

Abstract

A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula: (CNX)R, where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same or different is disclosed. Kits that can be used to form these complexes are also disclosed.

Inventors:
 [1];  [2];  [3];  [4]
  1. Newton Centre, MA
  2. Needham, MA
  3. Cambridge, MA
  4. Allston, MA
Issue Date:
Research Org.:
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
OSTI Identifier:
866559
Patent Number(s):
4735793
Application Number:
06/771,284
Assignee:
Massachusetts Institute of Technology (Cambridge, MA); President and Fellows of Harvard College (Cambridge, MA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
DOE Contract Number:  
AC02-76EV04115
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
carboxy; carboalkoxy; carbamile; substituted; isonitrile; radionuclide; complexes; coordination; complex; comprising; selected; consisting; radioactive; isotopes; tc; ru; ligand; formula; cnx; alkyl; carbon; atoms; coor; conr; pharmaceutically; acceptable; cation; unsubstituted; disclosed; kits; form; unsubstituted alkyl; radionuclide complexes; radioactive isotope; isonitrile ligand; carbon atoms; carbon atom; pharmaceutically acceptable; isonitrile radionuclide; radioactive isotopes; coordination complex; radionuclide selected; substituted isonitrile; complex comprising; substituted alkyl; carbamile substituted; /424/999/987/

Citation Formats

Jones, Alun G, Davison, Alan, Kronauge, James, and Abrams, Michael J. Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes. United States: N. p., 1988. Web.
Jones, Alun G, Davison, Alan, Kronauge, James, & Abrams, Michael J. Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes. United States.
Jones, Alun G, Davison, Alan, Kronauge, James, and Abrams, Michael J. Tue . "Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes". United States. https://www.osti.gov/servlets/purl/866559.
@article{osti_866559,
title = {Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes},
author = {Jones, Alun G and Davison, Alan and Kronauge, James and Abrams, Michael J},
abstractNote = {A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula: (CNX)R, where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same or different is disclosed. Kits that can be used to form these complexes are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1988},
month = {4}
}

Patent:

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