Alkyl phospholipid antihypertensive agents in method of lowering blood pressure
Abstract
The composition of this invention is 1-O-alkyl-2-acetoyl-sn-glycero-3-phosphocholine, having the ionic structural formula; ##STR1## wherein R is saturated alkyl having 9-21 carbon atoms, or salts or hydrates of the composition. Preferably R has 13-19 carbon atoms and most preferably R has 15 carbon atoms. The composition of this invention is useful for reducing hypertension in warm-blooded animals, including humans, when administered either orally or by injection or innoculation, e.g., intravenous injection. The composition can be prepared from naturally occurring lipids or synthetically from commercially available material.
- Inventors:
-
- Oak Ridge, TN
- Memphis, TN
- (late of Memphis, TN)
- Issue Date:
- Research Org.:
- Oak Ridge Associated Universities (ORAU), Oak Ridge, TN (United States)
- OSTI Identifier:
- 866503
- Patent Number(s):
- 4725588
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- AC05-76OR00033
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- alkyl; phospholipid; antihypertensive; agents; method; lowering; blood; pressure; composition; 1-o-alkyl-2-acetoyl-sn-glycero-3-phosphocholine; ionic; structural; formula; str1; saturated; 9-21; carbon; atoms; salts; hydrates; preferably; 13-19; 15; useful; reducing; hypertension; warm-blooded; animals; including; humans; administered; orally; injection; innoculation; intravenous; prepared; naturally; occurring; lipids; synthetically; commercially; available; material; naturally occurring; carbon atoms; commercially available; carbon atom; warm-blooded animals; including human; structural form; blood pressure; /514/999/
Citation Formats
Snyder, Fred L, Blank, Merle L, Muirhead, Ernest E, Leach, deceased, Byron E., and Byers, Lawrence W. Alkyl phospholipid antihypertensive agents in method of lowering blood pressure. United States: N. p., 1988.
Web.
Snyder, Fred L, Blank, Merle L, Muirhead, Ernest E, Leach, deceased, Byron E., & Byers, Lawrence W. Alkyl phospholipid antihypertensive agents in method of lowering blood pressure. United States.
Snyder, Fred L, Blank, Merle L, Muirhead, Ernest E, Leach, deceased, Byron E., and Byers, Lawrence W. Fri .
"Alkyl phospholipid antihypertensive agents in method of lowering blood pressure". United States. https://www.osti.gov/servlets/purl/866503.
@article{osti_866503,
title = {Alkyl phospholipid antihypertensive agents in method of lowering blood pressure},
author = {Snyder, Fred L and Blank, Merle L and Muirhead, Ernest E and Leach, deceased, Byron E. and Byers, Lawrence W},
abstractNote = {The composition of this invention is 1-O-alkyl-2-acetoyl-sn-glycero-3-phosphocholine, having the ionic structural formula; ##STR1## wherein R is saturated alkyl having 9-21 carbon atoms, or salts or hydrates of the composition. Preferably R has 13-19 carbon atoms and most preferably R has 15 carbon atoms. The composition of this invention is useful for reducing hypertension in warm-blooded animals, including humans, when administered either orally or by injection or innoculation, e.g., intravenous injection. The composition can be prepared from naturally occurring lipids or synthetically from commercially available material.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1988},
month = {1}
}
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