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Title: Nose-only exposure system

Abstract

An exposure system for supplying a gaseous material, i.e. an aerosol, gas or a vapor, directly to the noses of experimental animals includes concentric vertical inner and outer manifolds. The outer manifold connects with the necks of a large number of bottles in which the animals are confined with their noses adjacent the bottle necks. Readily detachable small tubes communicate with the inner manifold and extend to the necks of the bottles. The upper end of the outer manifold and the lower end of the inner manifold are closed. Gaseous material is supplied to the upper end of the inner manifold, flows through the small tubes to points adjacent the noses of the individual animals, then is drawn out through the bottom of the outer manifold. The bottles are readily removable and the device can be disassembled, e.g., for cleaning, by removing the bottles, removing the small tubes, and lifting the inner manifold from the outer manifold. The bottles are supported by engagement of their necks with the outer manifold supplemented, if additional support is required, by individual wire cradles. The outer ends of the bottles are closed by plugs, through which pass metal tubes which receive the tails ofmore » the animals (usually rodents) and which serve to dissipate body heat. The entire device is mounted for rotation on turntable bearings.« less

Inventors:
 [1];  [2];  [3]
  1. (Richland, WA)
  2. (Kennewick, WA)
  3. (Pasco, WA)
Issue Date:
Research Org.:
BATTELLE MEMORIAL INSTITUTE
OSTI Identifier:
866478
Patent Number(s):
4721060
Assignee:
Battelle Memorial Institute (Columbus, OH) PNNL
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
nose-only; exposure; supplying; gaseous; material; aerosol; gas; vapor; directly; noses; experimental; animals; concentric; vertical; inner; outer; manifolds; manifold; connects; necks; bottles; confined; adjacent; bottle; readily; detachable; tubes; communicate; extend; upper; closed; supplied; flows; individual; drawn; bottom; removable; device; disassembled; cleaning; removing; lifting; supported; engagement; supplemented; additional; support; required; wire; cradles; plugs; pass; metal; receive; tails; rodents; serve; dissipate; heat; entire; mounted; rotation; turntable; bearings; outer manifold; gaseous material; metal tube; readily removable; metal tubes; experimental animals; nose-only exposure; outer manifolds; entire device; manifold connects; /119/128/

Citation Formats

Cannon, William C., Bass, Edward W., and Decker, Jr., John R. Nose-only exposure system. United States: N. p., 1988. Web.
Cannon, William C., Bass, Edward W., & Decker, Jr., John R. Nose-only exposure system. United States.
Cannon, William C., Bass, Edward W., and Decker, Jr., John R. Fri . "Nose-only exposure system". United States. https://www.osti.gov/servlets/purl/866478.
@article{osti_866478,
title = {Nose-only exposure system},
author = {Cannon, William C. and Bass, Edward W. and Decker, Jr., John R.},
abstractNote = {An exposure system for supplying a gaseous material, i.e. an aerosol, gas or a vapor, directly to the noses of experimental animals includes concentric vertical inner and outer manifolds. The outer manifold connects with the necks of a large number of bottles in which the animals are confined with their noses adjacent the bottle necks. Readily detachable small tubes communicate with the inner manifold and extend to the necks of the bottles. The upper end of the outer manifold and the lower end of the inner manifold are closed. Gaseous material is supplied to the upper end of the inner manifold, flows through the small tubes to points adjacent the noses of the individual animals, then is drawn out through the bottom of the outer manifold. The bottles are readily removable and the device can be disassembled, e.g., for cleaning, by removing the bottles, removing the small tubes, and lifting the inner manifold from the outer manifold. The bottles are supported by engagement of their necks with the outer manifold supplemented, if additional support is required, by individual wire cradles. The outer ends of the bottles are closed by plugs, through which pass metal tubes which receive the tails of the animals (usually rodents) and which serve to dissipate body heat. The entire device is mounted for rotation on turntable bearings.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1988},
month = {1}
}

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