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Title: Electrophoresis-mass spectrometry probe

Abstract

The invention involves a new technique for the separation of complex mixtures of chemicals, which utilizes a unique interface probe for conventional mass spectrometers which allows the electrophoretically separated compounds to be analyzed in real-time by a mass spectrometer. This new chemical analysis interface, which couples electrophoresis with mass spectrometry, allows complex mixtures to be analyzed very rapidly, with much greater specificity, and with greater sensitivity. The interface or probe provides a means whereby large and/or polar molecules in complex mixtures to be completely characterized. The preferred embodiment of the probe utilizes a double capillary tip which allows the probe tip to be continually wetted by the buffer, which provides for increased heat dissipation, and results in a continually operating interface which is more durable and electronically stable than the illustrated single capillary tip probe interface.

Inventors:
 [1];  [2]
  1. Pleasanton, CA
  2. Livermore, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
866418
Patent Number(s):
4705616
Assignee:
Sepragen Corporation (San Leandro, CA)
Patent Classifications (CPCs):
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
electrophoresis-mass; spectrometry; probe; involves; technique; separation; complex; mixtures; chemicals; utilizes; unique; interface; conventional; mass; spectrometers; allows; electrophoretically; separated; compounds; analyzed; real-time; spectrometer; chemical; analysis; couples; electrophoresis; rapidly; specificity; sensitivity; provides; means; whereby; polar; molecules; completely; characterized; preferred; embodiment; double; capillary; tip; continually; wetted; buffer; increased; heat; dissipation; results; operating; durable; electronically; stable; illustrated; single; complex mixtures; means whereby; probe utilizes; chemical analysis; mass spectrometers; probe tip; mass spectrometer; preferred embodiment; mass spectrometry; heat dissipation; complex mixture; probe provides; conventional mass; increased heat; /204/250/436/

Citation Formats

Andresen, Brian D, and Fought, Eric R. Electrophoresis-mass spectrometry probe. United States: N. p., 1987. Web.
Andresen, Brian D, & Fought, Eric R. Electrophoresis-mass spectrometry probe. United States.
Andresen, Brian D, and Fought, Eric R. Thu . "Electrophoresis-mass spectrometry probe". United States. https://www.osti.gov/servlets/purl/866418.
@article{osti_866418,
title = {Electrophoresis-mass spectrometry probe},
author = {Andresen, Brian D and Fought, Eric R},
abstractNote = {The invention involves a new technique for the separation of complex mixtures of chemicals, which utilizes a unique interface probe for conventional mass spectrometers which allows the electrophoretically separated compounds to be analyzed in real-time by a mass spectrometer. This new chemical analysis interface, which couples electrophoresis with mass spectrometry, allows complex mixtures to be analyzed very rapidly, with much greater specificity, and with greater sensitivity. The interface or probe provides a means whereby large and/or polar molecules in complex mixtures to be completely characterized. The preferred embodiment of the probe utilizes a double capillary tip which allows the probe tip to be continually wetted by the buffer, which provides for increased heat dissipation, and results in a continually operating interface which is more durable and electronically stable than the illustrated single capillary tip probe interface.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1987},
month = {1}
}

Patent:

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