Excimer laser phototherapy for the dissolution of abnormal growth

Gruen, Dieter M; Young, Charles E; Pellin, Michael J

Title: Excimer laser phototherapy for the dissolution of abnormal growth

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Abstract

Removal of abnormal human tissue with reduced thermal damage is achieved by selecting a laser having a wavelength in the order of 290-400 nm, orienting a laser-transmitting glass member toward the abnormal tissue and directing the laser through the glass member at power densities, pulse rates, and times sufficient to cause multiphoton absorption and bond breaking by Coulomb repulsion rather than thermal destruction. The glass member may include a laser beam concentrator provided by a lens or cone at the tissue-treatment end to increase the beam energy per unit area and reduce the treatment area.

Inventors:

Gruen, Dieter M ^[1]; Young, Charles E ^[2]; Pellin, Michael J ^[3]

Downers Grove, IL
Westmont, IL
Naperville, IL

Issue Date:: 1987-01-01

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL (United States)

OSTI Identifier:: 866333

Patent Number(s):: 4686979

Assignee:: United States of America as represented by United States (Washington, DC)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61F - FILTERS IMPLANTABLE INTO BLOOD VESSELS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B18/245 - {for removing obstructions in blood vessels or calculi}
A61B2017/00154 - {pulsed}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61F - FILTERS IMPLANTABLE INTO BLOOD VESSELS
A61F2009/00863 - {Retina}
A61F9/008 - using laser

G - PHYSICS G02 - OPTICS G02B - OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
G02B6/4296 - {coupling with sources of high radiant energy, e.g. high power lasers, high temperature light sources}

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DOE Contract Number:: W-31109-ENG-38

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: excimer; laser; phototherapy; dissolution; abnormal; growth; removal; human; tissue; reduced; thermal; damage; achieved; selecting; wavelength; 290-400; nm; orienting; laser-transmitting; glass; directing; power; densities; pulse; rates; times; sufficient; multiphoton; absorption; bond; breaking; coulomb; repulsion; destruction; beam; concentrator; provided; lens; cone; tissue-treatment; increase; energy; unit; reduce; treatment; photon absorption; power densities; reduced thermal; thermal damage; laser beam; beam energy; excimer laser; pulse rate; normal human; human tissue; normal tissue; coulomb repulsion; thermal destruction; /606/

Citation Formats


                    Gruen, Dieter M, Young, Charles E, and Pellin, Michael J. Excimer laser phototherapy for the dissolution of abnormal growth.  United States: N. p., 1987. 
        Web.

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                    Gruen, Dieter M, Young, Charles E, & Pellin, Michael J. Excimer laser phototherapy for the dissolution of abnormal growth.  United States.

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                    Gruen, Dieter M, Young, Charles E, and Pellin, Michael J. Thu .  
        "Excimer laser phototherapy for the dissolution of abnormal growth".  United States.  https://www.osti.gov/servlets/purl/866333.

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@article{osti_866333,

  title        = {Excimer laser phototherapy for the dissolution of abnormal growth},

  author       = {Gruen, Dieter M and Young, Charles E and Pellin, Michael J},

  abstractNote = {Removal of abnormal human tissue with reduced thermal damage is achieved by selecting a laser having a wavelength in the order of 290-400 nm, orienting a laser-transmitting glass member toward the abnormal tissue and directing the laser through the glass member at power densities, pulse rates, and times sufficient to cause multiphoton absorption and bond breaking by Coulomb repulsion rather than thermal destruction. The glass member may include a laser beam concentrator provided by a lens or cone at the tissue-treatment end to increase the beam energy per unit area and reduce the treatment area.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1987},

  month        = {1}

}

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Excimer laser phototherapy for the dissolution of abnormal growth

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