Implantable apparatus for localized heating of tissue
Abstract
With the object of repetitively treating deep-seated, inoperable tumors by hyperthermia as well as locally heating other internal tissue masses repetitively, a receiving antenna, transmission line, and electrode arrangment are implanted completely within the patient's body, with the receiving antenna just under the surface of the skin and with the electrode arrangement being located so as to most effectively heat the tissue to be treated. An external, transmitting antenna, driven by an external radio-frequency energy source, is closely coupled to the implanted receiving antenna so that the energy coupled across the air-skin interface provides electromagnetic energy suitable for heating the tissue in the vicinity of the implanted electrodes. The resulting increase in tissue temperature may be estimated by an indirect measurement of the decrease in tissue resistivity in the heated region. This change in resistivity appears as a change in the loading of the receiving antenna which can be measured by either determining the change in the phase relationship between the voltage and the current appearing on the transmitting antenna or by measuring the change in the magnitude of the impedance thereof. Optionally, multiple electrode arrays may be activated or inactivated by the application of magnetic fields to operate implantedmore »
- Inventors:
-
- Los Alamos, NM
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- OSTI Identifier:
- 866306
- Patent Number(s):
- 4679561
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- implantable; apparatus; localized; heating; tissue; repetitively; treating; deep-seated; inoperable; tumors; hyperthermia; locally; internal; masses; receiving; antenna; transmission; line; electrode; arrangment; implanted; completely; patient; surface; arrangement; located; effectively; heat; treated; external; transmitting; driven; radio-frequency; energy; source; closely; coupled; air-skin; interface; provides; electromagnetic; suitable; vicinity; electrodes; resulting; increase; temperature; estimated; indirect; measurement; decrease; resistivity; heated; region; change; appears; loading; measured; determining; phase; relationship; voltage; current; appearing; measuring; magnitude; impedance; optionally; multiple; arrays; activated; inactivated; application; magnetic; fields; operate; reed; switches; direct measurement; localized heating; electrode array; transmitting antenna; transmission line; magnetic field; magnetic fields; energy source; electromagnetic energy; receiving antenna; multiple electrode; closely coupled; magnetic energy; reed switch; frequency energy; radio-frequency energy; phase relationship; direct measure; energy coupled; magnetic reed; tissue mass; interface provides; internal tissue; table apparatus; locally heating; /607/
Citation Formats
Doss, James D. Implantable apparatus for localized heating of tissue. United States: N. p., 1987.
Web.
Doss, James D. Implantable apparatus for localized heating of tissue. United States.
Doss, James D. Thu .
"Implantable apparatus for localized heating of tissue". United States. https://www.osti.gov/servlets/purl/866306.
@article{osti_866306,
title = {Implantable apparatus for localized heating of tissue},
author = {Doss, James D},
abstractNote = {With the object of repetitively treating deep-seated, inoperable tumors by hyperthermia as well as locally heating other internal tissue masses repetitively, a receiving antenna, transmission line, and electrode arrangment are implanted completely within the patient's body, with the receiving antenna just under the surface of the skin and with the electrode arrangement being located so as to most effectively heat the tissue to be treated. An external, transmitting antenna, driven by an external radio-frequency energy source, is closely coupled to the implanted receiving antenna so that the energy coupled across the air-skin interface provides electromagnetic energy suitable for heating the tissue in the vicinity of the implanted electrodes. The resulting increase in tissue temperature may be estimated by an indirect measurement of the decrease in tissue resistivity in the heated region. This change in resistivity appears as a change in the loading of the receiving antenna which can be measured by either determining the change in the phase relationship between the voltage and the current appearing on the transmitting antenna or by measuring the change in the magnitude of the impedance thereof. Optionally, multiple electrode arrays may be activated or inactivated by the application of magnetic fields to operate implanted magnetic reed switches.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 1987},
month = {Thu Jan 01 00:00:00 EST 1987}
}