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Title: Rapid brain scanning radiopharmaceutical

Abstract

A method for detecting the blood flow in animals, particularly in the brain, is provided wherein a detectable amount of a novel radioactive compound of the formula I is administered to one animal: ##STR1## wherein R.sub.1 and R.sub.2 are independently alkyl of 1 to 6 carbon atoms or benzyl; R.sub.3 is alkyl of 1 to 6 carbon atoms, benzyl, cyclopropylalkyl of 4 to 6 carbon atoms, or cyanoalkyl of 2 to 6 carbon atoms; R.sub.4 is hydrogen, benzyl or alkyl of 1 to 6 carbon atoms; with the provisos that R.sub.4 is not isopropyl and when R.sub.4 is methyl, R.sub.3 is not benzyl; and X is a radioactive halogen.

Inventors:
 [1];  [2];  [3]
  1. (Berkeley, CA)
  2. Lafayette, CA
  3. Oakland, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
866163
Patent Number(s):
4647446
Assignee:
Regents of University of California (Berkeley, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
rapid; brain; scanning; radiopharmaceutical; method; detecting; blood; flow; animals; particularly; provided; detectable; amount; novel; radioactive; compound; formula; administered; animal; str1; independently; alkyl; carbon; atoms; benzyl; cyclopropylalkyl; cyanoalkyl; hydrogen; provisos; isopropyl; methyl; halogen; blood flow; carbon atoms; carbon atom; radioactive compound; active compound; rapid brain; novel radioactive; detectable amount; /424/999/

Citation Formats

Sargent, III, Thornton W., Shulgin, Alexander T, and Mathis, Chester A. Rapid brain scanning radiopharmaceutical. United States: N. p., 1987. Web.
Sargent, III, Thornton W., Shulgin, Alexander T, & Mathis, Chester A. Rapid brain scanning radiopharmaceutical. United States.
Sargent, III, Thornton W., Shulgin, Alexander T, and Mathis, Chester A. Thu . "Rapid brain scanning radiopharmaceutical". United States. https://www.osti.gov/servlets/purl/866163.
@article{osti_866163,
title = {Rapid brain scanning radiopharmaceutical},
author = {Sargent, III, Thornton W. and Shulgin, Alexander T and Mathis, Chester A},
abstractNote = {A method for detecting the blood flow in animals, particularly in the brain, is provided wherein a detectable amount of a novel radioactive compound of the formula I is administered to one animal: ##STR1## wherein R.sub.1 and R.sub.2 are independently alkyl of 1 to 6 carbon atoms or benzyl; R.sub.3 is alkyl of 1 to 6 carbon atoms, benzyl, cyclopropylalkyl of 4 to 6 carbon atoms, or cyanoalkyl of 2 to 6 carbon atoms; R.sub.4 is hydrogen, benzyl or alkyl of 1 to 6 carbon atoms; with the provisos that R.sub.4 is not isopropyl and when R.sub.4 is methyl, R.sub.3 is not benzyl; and X is a radioactive halogen.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1987},
month = {1}
}

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