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Title: In-vivo measurement of lithium in the brain and other organs

Abstract

The lithium used clinically and distributed in organs such as the brain or idney of humans and other exhaling animals is determined in-vivo by means of neutron radiation and measuring in the exhaled air elemental tritiated hydrogen released from the tritium reaction by the reaction .sup.6 Li(n,.alpha.)T. The tritium atoms so released are transformed in part in the surrounding aqueous solution to form gaseous tritiated hydrogen which has a small solubility in body tissues and liquids and thus appears quickly in the breath. After a recipient fasts and is irradiated with neutrons, the air exhaled in the breath for a given time after irradiation is captured and processed to remove water, isolate hydrogen and measure the tritiated hydrogen with a gaseous organ-methane counter.

Inventors:
 [1];  [2];  [3];  [4];  [5]
  1. (Yavne, IL)
  2. (Shirley, NY)
  3. (Wading River, NY)
  4. (Bayport, NY)
  5. (Smithtown, NY)
Issue Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
865688
Patent Number(s):
4556068
Assignee:
United States of America as represented by Department of Energy (Washington, DC) BNL
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
in-vivo; measurement; lithium; brain; organs; clinically; distributed; idney; humans; exhaling; animals; determined; means; neutron; radiation; measuring; exhaled; air; elemental; tritiated; hydrogen; released; tritium; reaction; alpha; atoms; transformed; surrounding; aqueous; solution; form; gaseous; solubility; tissues; liquids; appears; quickly; breath; recipient; fasts; irradiated; neutrons; time; irradiation; captured; processed; remove; water; isolate; measure; organ-methane; counter; neutron radiation; aqueous solution; remove water; tritium atoms; form gaseous; vivo measurement; move water; /600/

Citation Formats

Vartsky, David, Wielopolski, Lucian, LoMonte, Anthony F., Ellis, Kenneth J., and Cohn, Stanton H. In-vivo measurement of lithium in the brain and other organs. United States: N. p., 1985. Web.
Vartsky, David, Wielopolski, Lucian, LoMonte, Anthony F., Ellis, Kenneth J., & Cohn, Stanton H. In-vivo measurement of lithium in the brain and other organs. United States.
Vartsky, David, Wielopolski, Lucian, LoMonte, Anthony F., Ellis, Kenneth J., and Cohn, Stanton H. Tue . "In-vivo measurement of lithium in the brain and other organs". United States. https://www.osti.gov/servlets/purl/865688.
@article{osti_865688,
title = {In-vivo measurement of lithium in the brain and other organs},
author = {Vartsky, David and Wielopolski, Lucian and LoMonte, Anthony F. and Ellis, Kenneth J. and Cohn, Stanton H.},
abstractNote = {The lithium used clinically and distributed in organs such as the brain or idney of humans and other exhaling animals is determined in-vivo by means of neutron radiation and measuring in the exhaled air elemental tritiated hydrogen released from the tritium reaction by the reaction .sup.6 Li(n,.alpha.)T. The tritium atoms so released are transformed in part in the surrounding aqueous solution to form gaseous tritiated hydrogen which has a small solubility in body tissues and liquids and thus appears quickly in the breath. After a recipient fasts and is irradiated with neutrons, the air exhaled in the breath for a given time after irradiation is captured and processed to remove water, isolate hydrogen and measure the tritiated hydrogen with a gaseous organ-methane counter.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1985},
month = {1}
}

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