Method and apparatus for molecular imaging using X-rays at resonance wavelengths
Abstract
Holographic X-ray images are produced representing the molecular structure of a microscopic object, such as a living cell, by directing a beam of coherent X-rays upon the object to produce scattering of the X-rays by the object, producing interference on a recording medium between the scattered X-rays from the object and unscattered coherent X-rays and thereby producing holograms on the recording surface, and establishing the wavelength of the coherent X-rays to correspond with a molecular resonance of a constituent of such object and thereby greatly improving the contrast, sensitivity and resolution of the holograms as representations of molecular structures involving such constituent. For example, the coherent X-rays may be adjusted to the molecular resonant absorption line of nitrogen at about 401.3 eV to produce holographic images featuring molecular structures involving nitrogen.
- Inventors:
-
- (Alamo, CA)
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- OSTI Identifier:
- 865560
- Patent Number(s):
- 4536883
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
G - PHYSICS G03 - PHOTOGRAPHY G03H - HOLOGRAPHIC PROCESSES OR APPARATUS
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; apparatus; molecular; imaging; x-rays; resonance; wavelengths; holographic; x-ray; images; produced; representing; structure; microscopic; living; cell; directing; beam; coherent; produce; scattering; producing; interference; recording; medium; scattered; unscattered; holograms; surface; establishing; wavelength; correspond; constituent; greatly; improving; contrast; sensitivity; resolution; representations; structures; involving; example; adjusted; resonant; absorption; line; nitrogen; 401; featuring; x-ray image; coherent x-rays; absorption line; molecular structure; recording medium; holographic image; holographic images; scattered x-ray; resonance wavelengths; resonance wavelength; greatly improving; x-ray images; /378/
Citation Formats
Chapline, Jr., George F. Method and apparatus for molecular imaging using X-rays at resonance wavelengths. United States: N. p., 1985.
Web.
Chapline, Jr., George F. Method and apparatus for molecular imaging using X-rays at resonance wavelengths. United States.
Chapline, Jr., George F. Tue .
"Method and apparatus for molecular imaging using X-rays at resonance wavelengths". United States. https://www.osti.gov/servlets/purl/865560.
@article{osti_865560,
title = {Method and apparatus for molecular imaging using X-rays at resonance wavelengths},
author = {Chapline, Jr., George F.},
abstractNote = {Holographic X-ray images are produced representing the molecular structure of a microscopic object, such as a living cell, by directing a beam of coherent X-rays upon the object to produce scattering of the X-rays by the object, producing interference on a recording medium between the scattered X-rays from the object and unscattered coherent X-rays and thereby producing holograms on the recording surface, and establishing the wavelength of the coherent X-rays to correspond with a molecular resonance of a constituent of such object and thereby greatly improving the contrast, sensitivity and resolution of the holograms as representations of molecular structures involving such constituent. For example, the coherent X-rays may be adjusted to the molecular resonant absorption line of nitrogen at about 401.3 eV to produce holographic images featuring molecular structures involving nitrogen.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1985},
month = {Tue Jan 01 00:00:00 EST 1985}
}