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Title: Method and apparatus for molecular imaging using X-rays at resonance wavelengths

Abstract

Holographic X-ray images are produced representing the molecular structure of a microscopic object, such as a living cell, by directing a beam of coherent X-rays upon the object to produce scattering of the X-rays by the object, producing interference on a recording medium between the scattered X-rays from the object and unscattered coherent X-rays and thereby producing holograms on the recording surface, and establishing the wavelength of the coherent X-rays to correspond with a molecular resonance of a constituent of such object and thereby greatly improving the contrast, sensitivity and resolution of the holograms as representations of molecular structures involving such constituent. For example, the coherent X-rays may be adjusted to the molecular resonant absorption line of nitrogen at about 401.3 eV to produce holographic images featuring molecular structures involving nitrogen.

Inventors:
 [1]
  1. (Alamo, CA)
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
865560
Patent Number(s):
4536883
Assignee:
United States of America as represented by United States (Washington, DC)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; apparatus; molecular; imaging; x-rays; resonance; wavelengths; holographic; x-ray; images; produced; representing; structure; microscopic; living; cell; directing; beam; coherent; produce; scattering; producing; interference; recording; medium; scattered; unscattered; holograms; surface; establishing; wavelength; correspond; constituent; greatly; improving; contrast; sensitivity; resolution; representations; structures; involving; example; adjusted; resonant; absorption; line; nitrogen; 401; featuring; x-ray image; coherent x-rays; absorption line; molecular structure; recording medium; holographic image; holographic images; scattered x-ray; resonance wavelengths; resonance wavelength; greatly improving; x-ray images; /378/

Citation Formats

Chapline, Jr., George F. Method and apparatus for molecular imaging using X-rays at resonance wavelengths. United States: N. p., 1985. Web.
Chapline, Jr., George F. Method and apparatus for molecular imaging using X-rays at resonance wavelengths. United States.
Chapline, Jr., George F. Tue . "Method and apparatus for molecular imaging using X-rays at resonance wavelengths". United States. https://www.osti.gov/servlets/purl/865560.
@article{osti_865560,
title = {Method and apparatus for molecular imaging using X-rays at resonance wavelengths},
author = {Chapline, Jr., George F.},
abstractNote = {Holographic X-ray images are produced representing the molecular structure of a microscopic object, such as a living cell, by directing a beam of coherent X-rays upon the object to produce scattering of the X-rays by the object, producing interference on a recording medium between the scattered X-rays from the object and unscattered coherent X-rays and thereby producing holograms on the recording surface, and establishing the wavelength of the coherent X-rays to correspond with a molecular resonance of a constituent of such object and thereby greatly improving the contrast, sensitivity and resolution of the holograms as representations of molecular structures involving such constituent. For example, the coherent X-rays may be adjusted to the molecular resonant absorption line of nitrogen at about 401.3 eV to produce holographic images featuring molecular structures involving nitrogen.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1985},
month = {1}
}

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