skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Tin-117m-labeled stannic (Sn.sup.4+) chelates

Abstract

The radiopharmaceutical reagents of this invention and the class of Tin-117m radiopharmaceuticals are therapeutic and diagnostic agents that incorporate gamma-emitting nuclides that localize in bone after intravenous injection in mammals (mice, rats, dogs, and rabbits). Images reflecting bone structure or function can then be obtained by a scintillation camera that detects the distribution of ionizing radiation emitted by the radioactive agent. Tin-117m-labeled chelates of stannic tin localize almost exclusively in cortical bone. Upon intravenous injection of the reagent, the preferred chelates are phosphonate compounds, preferable, PYP, MDP, EHDP, and DTPA. This class of reagents is therapeutically and diagnostically useful in skeletal scintigraphy and for the radiotherapy of bone tumors and other disorders.

Inventors:
 [1];  [2];  [3]
  1. (Setauket, NY)
  2. (Middle Island, NY)
  3. (Bayport, NY)
Issue Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
865544
Patent Number(s):
4533541
Assignee:
United States of America as represented by United States (Washington, DC) BNL
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
tin-117m-labeled; stannic; chelates; radiopharmaceutical; reagents; tin-117m; radiopharmaceuticals; therapeutic; diagnostic; agents; incorporate; gamma-emitting; nuclides; localize; bone; intravenous; injection; mammals; mice; rats; dogs; rabbits; images; reflecting; structure; function; obtained; scintillation; camera; detects; distribution; ionizing; radiation; emitted; radioactive; agent; exclusively; cortical; reagent; preferred; phosphonate; compounds; preferable; pyp; mdp; ehdp; dtpa; therapeutically; diagnostically; useful; skeletal; scintigraphy; radiotherapy; tumors; disorders; ionizing radiation; radiation emitted; scintillation camera; diagnostically useful; diagnostic agent; diagnostic agents; /424/999/

Citation Formats

Srivastava, Suresh C., Meinken, George E., and Richards, Powell. Tin-117m-labeled stannic (Sn.sup.4+) chelates. United States: N. p., 1985. Web.
Srivastava, Suresh C., Meinken, George E., & Richards, Powell. Tin-117m-labeled stannic (Sn.sup.4+) chelates. United States.
Srivastava, Suresh C., Meinken, George E., and Richards, Powell. Tue . "Tin-117m-labeled stannic (Sn.sup.4+) chelates". United States. https://www.osti.gov/servlets/purl/865544.
@article{osti_865544,
title = {Tin-117m-labeled stannic (Sn.sup.4+) chelates},
author = {Srivastava, Suresh C. and Meinken, George E. and Richards, Powell},
abstractNote = {The radiopharmaceutical reagents of this invention and the class of Tin-117m radiopharmaceuticals are therapeutic and diagnostic agents that incorporate gamma-emitting nuclides that localize in bone after intravenous injection in mammals (mice, rats, dogs, and rabbits). Images reflecting bone structure or function can then be obtained by a scintillation camera that detects the distribution of ionizing radiation emitted by the radioactive agent. Tin-117m-labeled chelates of stannic tin localize almost exclusively in cortical bone. Upon intravenous injection of the reagent, the preferred chelates are phosphonate compounds, preferable, PYP, MDP, EHDP, and DTPA. This class of reagents is therapeutically and diagnostically useful in skeletal scintigraphy and for the radiotherapy of bone tumors and other disorders.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1985},
month = {1}
}

Patent:

Save / Share: