Tin-117m-labeled stannic (Sn.sup.4+) chelates
Abstract
The radiopharmaceutical reagents of this invention and the class of Tin-117m radiopharmaceuticals are therapeutic and diagnostic agents that incorporate gamma-emitting nuclides that localize in bone after intravenous injection in mammals (mice, rats, dogs, and rabbits). Images reflecting bone structure or function can then be obtained by a scintillation camera that detects the distribution of ionizing radiation emitted by the radioactive agent. Tin-117m-labeled chelates of stannic tin localize almost exclusively in cortical bone. Upon intravenous injection of the reagent, the preferred chelates are phosphonate compounds, preferable, PYP, MDP, EHDP, and DTPA. This class of reagents is therapeutically and diagnostically useful in skeletal scintigraphy and for the radiotherapy of bone tumors and other disorders.
- Inventors:
-
- Setauket, NY
- Middle Island, NY
- Bayport, NY
- Issue Date:
- Research Org.:
- Associated Universities, Inc., Upton, NY (United States)
- OSTI Identifier:
- 865544
- Patent Number(s):
- 4533541
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- tin-117m-labeled; stannic; chelates; radiopharmaceutical; reagents; tin-117m; radiopharmaceuticals; therapeutic; diagnostic; agents; incorporate; gamma-emitting; nuclides; localize; bone; intravenous; injection; mammals; mice; rats; dogs; rabbits; images; reflecting; structure; function; obtained; scintillation; camera; detects; distribution; ionizing; radiation; emitted; radioactive; agent; exclusively; cortical; reagent; preferred; phosphonate; compounds; preferable; pyp; mdp; ehdp; dtpa; therapeutically; diagnostically; useful; skeletal; scintigraphy; radiotherapy; tumors; disorders; ionizing radiation; radiation emitted; scintillation camera; diagnostically useful; diagnostic agent; diagnostic agents; /424/999/
Citation Formats
Srivastava, Suresh C, Meinken, George E, and Richards, Powell. Tin-117m-labeled stannic (Sn.sup.4+) chelates. United States: N. p., 1985.
Web.
Srivastava, Suresh C, Meinken, George E, & Richards, Powell. Tin-117m-labeled stannic (Sn.sup.4+) chelates. United States.
Srivastava, Suresh C, Meinken, George E, and Richards, Powell. Tue .
"Tin-117m-labeled stannic (Sn.sup.4+) chelates". United States. https://www.osti.gov/servlets/purl/865544.
@article{osti_865544,
title = {Tin-117m-labeled stannic (Sn.sup.4+) chelates},
author = {Srivastava, Suresh C and Meinken, George E and Richards, Powell},
abstractNote = {The radiopharmaceutical reagents of this invention and the class of Tin-117m radiopharmaceuticals are therapeutic and diagnostic agents that incorporate gamma-emitting nuclides that localize in bone after intravenous injection in mammals (mice, rats, dogs, and rabbits). Images reflecting bone structure or function can then be obtained by a scintillation camera that detects the distribution of ionizing radiation emitted by the radioactive agent. Tin-117m-labeled chelates of stannic tin localize almost exclusively in cortical bone. Upon intravenous injection of the reagent, the preferred chelates are phosphonate compounds, preferable, PYP, MDP, EHDP, and DTPA. This class of reagents is therapeutically and diagnostically useful in skeletal scintigraphy and for the radiotherapy of bone tumors and other disorders.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1985},
month = {1}
}