Mutation assays involving blood cells that metabolize toxic substances
Abstract
A line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity) is disclosed. Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. Mutation assays using these cells, and other cells with similar characteristics, are also disclosed.
- Inventors:
-
- Downers Grove, IL
- Winchester, MA
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- OSTI Identifier:
- 865535
- Patent Number(s):
- 4532204
- Assignee:
- Massachusetts Institute of Technology (Cambridge, MA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C02 - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE C02F - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
F - MECHANICAL ENGINEERING F24 - HEATING F24D - DOMESTIC- OR SPACE-HEATING SYSTEMS, e.g. CENTRAL HEATING SYSTEMS
- DOE Contract Number:
- AC04-76
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- mutation; assays; involving; blood; cells; metabolize; toxic; substances; line; human; levels; oxidative; activity; oxygenase; oxidase; peroxidase; hydroxylase; disclosed; grow; suspension; culture; useful; determine; mutagenicity; xenobiotic; metabolized; mutagenic; similar; characteristics; blood cells; blood cell; mutation assays; human blood; metabolize toxic; oxidative activity; suspension culture; toxic substances; hydroxylase activity; cells grow; assays involving; involving blood; /435/
Citation Formats
Crespi, Charles L, and Thilly, William G. Mutation assays involving blood cells that metabolize toxic substances. United States: N. p., 1985.
Web.
Crespi, Charles L, & Thilly, William G. Mutation assays involving blood cells that metabolize toxic substances. United States.
Crespi, Charles L, and Thilly, William G. Tue .
"Mutation assays involving blood cells that metabolize toxic substances". United States. https://www.osti.gov/servlets/purl/865535.
@article{osti_865535,
title = {Mutation assays involving blood cells that metabolize toxic substances},
author = {Crespi, Charles L and Thilly, William G},
abstractNote = {A line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity) is disclosed. Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. Mutation assays using these cells, and other cells with similar characteristics, are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1985},
month = {1}
}
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