High pressure liquid chromatographic gradient mixer
Abstract
A gradient mixer which effects the continuous mixing of any two miscible solvents without excessive decay or dispersion of the resultant isocratic effluent or of a linear or exponential gradient. The two solvents are fed under low or high pressure by means of two high performance liquid chromatographic pumps. The mixer comprises a series of ultra-low dead volume stainless steel tubes and low dead volume chambers. The two solvent streams impinge head-on at high fluxes. This initial nonhomogeneous mixture is then passed through a chamber packed with spirally-wound wires which cause turbulent mixing thereby homogenizing the mixture with minimum "band-broadening".
- Inventors:
-
- San Pablo, CA
- El Cerrito, CA
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- OSTI Identifier:
- 865383
- Patent Number(s):
- 4506987
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- pressure; liquid; chromatographic; gradient; mixer; effects; continuous; mixing; miscible; solvents; excessive; decay; dispersion; resultant; isocratic; effluent; linear; exponential; fed; means; performance; pumps; comprises; series; ultra-low; dead; volume; stainless; steel; tubes; chambers; solvent; streams; impinge; head-on; fluxes; initial; nonhomogeneous; mixture; passed; chamber; packed; spirally-wound; wires; turbulent; homogenizing; minimum; band-broadening; performance liquid; liquid chromatograph; dead volume; stainless steel; homogeneous mixture; liquid chromatographic; pressure liquid; turbulent mixing; solvent stream; volume chambers; gradient mixer; miscible solvents; /366/210/
Citation Formats
Daughton, Christian G, and Sakaji, Richard H. High pressure liquid chromatographic gradient mixer. United States: N. p., 1985.
Web.
Daughton, Christian G, & Sakaji, Richard H. High pressure liquid chromatographic gradient mixer. United States.
Daughton, Christian G, and Sakaji, Richard H. Tue .
"High pressure liquid chromatographic gradient mixer". United States. https://www.osti.gov/servlets/purl/865383.
@article{osti_865383,
title = {High pressure liquid chromatographic gradient mixer},
author = {Daughton, Christian G and Sakaji, Richard H},
abstractNote = {A gradient mixer which effects the continuous mixing of any two miscible solvents without excessive decay or dispersion of the resultant isocratic effluent or of a linear or exponential gradient. The two solvents are fed under low or high pressure by means of two high performance liquid chromatographic pumps. The mixer comprises a series of ultra-low dead volume stainless steel tubes and low dead volume chambers. The two solvent streams impinge head-on at high fluxes. This initial nonhomogeneous mixture is then passed through a chamber packed with spirally-wound wires which cause turbulent mixing thereby homogenizing the mixture with minimum "band-broadening".},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1985},
month = {1}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.