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Title: High pressure liquid chromatographic gradient mixer

Abstract

A gradient mixer which effects the continuous mixing of any two miscible solvents without excessive decay or dispersion of the resultant isocratic effluent or of a linear or exponential gradient. The two solvents are fed under low or high pressure by means of two high performance liquid chromatographic pumps. The mixer comprises a series of ultra-low dead volume stainless steel tubes and low dead volume chambers. The two solvent streams impinge head-on at high fluxes. This initial nonhomogeneous mixture is then passed through a chamber packed with spirally-wound wires which cause turbulent mixing thereby homogenizing the mixture with minimum "band-broadening".

Inventors:
 [1];  [2]
  1. (San Pablo, CA)
  2. (El Cerrito, CA)
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
865383
Patent Number(s):
4506987
Assignee:
United States of America as represented by United States (Washington, DC) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
pressure; liquid; chromatographic; gradient; mixer; effects; continuous; mixing; miscible; solvents; excessive; decay; dispersion; resultant; isocratic; effluent; linear; exponential; fed; means; performance; pumps; comprises; series; ultra-low; dead; volume; stainless; steel; tubes; chambers; solvent; streams; impinge; head-on; fluxes; initial; nonhomogeneous; mixture; passed; chamber; packed; spirally-wound; wires; turbulent; homogenizing; minimum; band-broadening; performance liquid; liquid chromatograph; dead volume; stainless steel; homogeneous mixture; liquid chromatographic; pressure liquid; turbulent mixing; solvent stream; volume chambers; gradient mixer; miscible solvents; /366/210/

Citation Formats

Daughton, Christian G., and Sakaji, Richard H. High pressure liquid chromatographic gradient mixer. United States: N. p., 1985. Web.
Daughton, Christian G., & Sakaji, Richard H. High pressure liquid chromatographic gradient mixer. United States.
Daughton, Christian G., and Sakaji, Richard H. Tue . "High pressure liquid chromatographic gradient mixer". United States. https://www.osti.gov/servlets/purl/865383.
@article{osti_865383,
title = {High pressure liquid chromatographic gradient mixer},
author = {Daughton, Christian G. and Sakaji, Richard H.},
abstractNote = {A gradient mixer which effects the continuous mixing of any two miscible solvents without excessive decay or dispersion of the resultant isocratic effluent or of a linear or exponential gradient. The two solvents are fed under low or high pressure by means of two high performance liquid chromatographic pumps. The mixer comprises a series of ultra-low dead volume stainless steel tubes and low dead volume chambers. The two solvent streams impinge head-on at high fluxes. This initial nonhomogeneous mixture is then passed through a chamber packed with spirally-wound wires which cause turbulent mixing thereby homogenizing the mixture with minimum "band-broadening".},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1985},
month = {1}
}

Patent:

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