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Title: Complex of transferrin with ruthenium for medical applications

Abstract

A novel Ruthenium-transferrin complex, prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40.degree. C. for about 2 hours, and purifying said complex by means of gel chromotography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparative results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex.

Inventors:
 [1];  [2];  [3]
  1. Bayport, NY
  2. Setauket, NY
  3. Middle Island, NY
Issue Date:
Research Org.:
Associated Universities, Inc., Upton, NY (United States)
OSTI Identifier:
865008
Patent Number(s):
4448762
Application Number:
06/203,194
Assignee:
United States of America as represented by United States (Washington, DC)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
complex; transferrin; ruthenium; medical; applications; novel; ruthenium-transferrin; prepared; reacting; iron-free; human; dissolved; sodium; acetate; solution; ph; heating; 40; degree; hours; purifying; means; chromotography; eluent; mono-; di-metal; produced; nuclear; medicine; diagnosis; treatment; tumors; abscesses; comparative; results; ga-67-citrate; widely; tumor-localizing; agent; indicate; increased; sensitivity; detection; tumor; uptake; ru-transferrin; increased sensitivity; medical applications; nuclear medicine; metal complex; sodium acetate; tumor uptake; acetate solution; /424/530/

Citation Formats

Richards, Powell, Srivastava, Suresh C, and Meinken, George E. Complex of transferrin with ruthenium for medical applications. United States: N. p., 1984. Web.
Richards, Powell, Srivastava, Suresh C, & Meinken, George E. Complex of transferrin with ruthenium for medical applications. United States.
Richards, Powell, Srivastava, Suresh C, and Meinken, George E. Tue . "Complex of transferrin with ruthenium for medical applications". United States. https://www.osti.gov/servlets/purl/865008.
@article{osti_865008,
title = {Complex of transferrin with ruthenium for medical applications},
author = {Richards, Powell and Srivastava, Suresh C and Meinken, George E},
abstractNote = {A novel Ruthenium-transferrin complex, prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40.degree. C. for about 2 hours, and purifying said complex by means of gel chromotography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparative results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1984},
month = {5}
}

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