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Title: Polycatecholamide chelating agents

Abstract

Novel polybenzamide compounds useful for in vitro or in vivo chelation are described. The compounds have the formula ##STR1## Polyamines are reacted with 2,3-dimethoxy benzoyl chloride unsubstituted or substituted with SO.sub.3 H, SO.sub.3 M, NO.sub.2, CO.sub.2 H or CO.sub.2 M as desired is reacted with a polyamine in an inert solvent then demethylated with BBr.sub.3 or BCl.sub.3 in an inert solvent. Where compounds symmetrically substituted on the terminal N's are desired, the polyamine is first reductively alkylated by reaction with an aldehyde or ketone and the resulting Schiff base is hydrogenated.

Inventors:
 [1];  [2]
  1. Martinez, CA
  2. Berkeley, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
864952
Patent Number(s):
4442305
Assignee:
United States of America as represented by United States (Washington, DC)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
polycatecholamide; chelating; agents; novel; polybenzamide; compounds; useful; vitro; vivo; chelation; described; formula; str1; polyamines; reacted; 3-dimethoxy; benzoyl; chloride; unsubstituted; substituted; desired; polyamine; inert; solvent; demethylated; bbr; bcl; symmetrically; terminal; reductively; alkylated; reaction; aldehyde; ketone; resulting; schiff; base; hydrogenated; compounds useful; chelating agents; chelating agent; inert solvent; schiff base; /514/423/999/

Citation Formats

Weitl, Frederick L, and Raymond, Kenneth N. Polycatecholamide chelating agents. United States: N. p., 1984. Web.
Weitl, Frederick L, & Raymond, Kenneth N. Polycatecholamide chelating agents. United States.
Weitl, Frederick L, and Raymond, Kenneth N. Sun . "Polycatecholamide chelating agents". United States. https://www.osti.gov/servlets/purl/864952.
@article{osti_864952,
title = {Polycatecholamide chelating agents},
author = {Weitl, Frederick L and Raymond, Kenneth N},
abstractNote = {Novel polybenzamide compounds useful for in vitro or in vivo chelation are described. The compounds have the formula ##STR1## Polyamines are reacted with 2,3-dimethoxy benzoyl chloride unsubstituted or substituted with SO.sub.3 H, SO.sub.3 M, NO.sub.2, CO.sub.2 H or CO.sub.2 M as desired is reacted with a polyamine in an inert solvent then demethylated with BBr.sub.3 or BCl.sub.3 in an inert solvent. Where compounds symmetrically substituted on the terminal N's are desired, the polyamine is first reductively alkylated by reaction with an aldehyde or ketone and the resulting Schiff base is hydrogenated.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1984},
month = {1}
}

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