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Title: .sup.18 F-4-Fluoroantipyrine

Abstract

The novel radioactive compound .sup.18 F-4-fluoroantipyrine having high specific activity which can be used in nuclear medicine in diagnostic applications, prepared by the direct fluorination of antipyrine in acetic acid with radioactive fluorine at room temperature and purifying said radioactive compound by means of gel chromatography with ethyl acetate as eluent is disclosed. The non-radioactive 4-fluoroantipyrine can also be prepared by the direct fluorination of antipyrine in acetic acid with molecular fluorine at room temperature and purified by means of gel chromotography with ethyl acetate eluent.

Inventors:
 [1];  [2]
  1. (Wading River, NY)
  2. (Setauket, NY)
Issue Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
864913
Patent Number(s):
4436717
Application Number:
06/268,422
Assignee:
United States of America as represented by United States (Washington, DC) BNL
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
18; f-4-fluoroantipyrine; novel; radioactive; compound; specific; activity; nuclear; medicine; diagnostic; applications; prepared; direct; fluorination; antipyrine; acetic; acid; fluorine; temperature; purifying; means; chromatography; ethyl; acetate; eluent; disclosed; non-radioactive; 4-fluoroantipyrine; molecular; purified; chromotography; acetic acid; nuclear medicine; ethyl acetate; specific activity; radioactive compound; active compound; direct fluorination; novel radioactive; diagnostic applications; /424/376/999/

Citation Formats

Shiue, Chyng-Yann, and Wolf, Alfred P. .sup.18 F-4-Fluoroantipyrine. United States: N. p., 1984. Web.
Shiue, Chyng-Yann, & Wolf, Alfred P. .sup.18 F-4-Fluoroantipyrine. United States.
Shiue, Chyng-Yann, and Wolf, Alfred P. Tue . ".sup.18 F-4-Fluoroantipyrine". United States. https://www.osti.gov/servlets/purl/864913.
@article{osti_864913,
title = {.sup.18 F-4-Fluoroantipyrine},
author = {Shiue, Chyng-Yann and Wolf, Alfred P.},
abstractNote = {The novel radioactive compound .sup.18 F-4-fluoroantipyrine having high specific activity which can be used in nuclear medicine in diagnostic applications, prepared by the direct fluorination of antipyrine in acetic acid with radioactive fluorine at room temperature and purifying said radioactive compound by means of gel chromatography with ethyl acetate as eluent is disclosed. The non-radioactive 4-fluoroantipyrine can also be prepared by the direct fluorination of antipyrine in acetic acid with molecular fluorine at room temperature and purified by means of gel chromotography with ethyl acetate eluent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1984},
month = {3}
}

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