.sup.18 F-4-Fluoroantipyrine
Abstract
The novel radioactive compound .sup.18 F-4-fluoroantipyrine having high specific activity which can be used in nuclear medicine in diagnostic applications, prepared by the direct fluorination of antipyrine in acetic acid with radioactive fluorine at room temperature and purifying said radioactive compound by means of gel chromatography with ethyl acetate as eluent is disclosed. The non-radioactive 4-fluoroantipyrine can also be prepared by the direct fluorination of antipyrine in acetic acid with molecular fluorine at room temperature and purified by means of gel chromotography with ethyl acetate eluent.
- Inventors:
-
- Wading River, NY
- Setauket, NY
- Issue Date:
- Research Org.:
- Associated Universities, Inc., Upton, NY (United States)
- OSTI Identifier:
- 864913
- Patent Number(s):
- 4436717
- Application Number:
- 06/268,422
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 18; f-4-fluoroantipyrine; novel; radioactive; compound; specific; activity; nuclear; medicine; diagnostic; applications; prepared; direct; fluorination; antipyrine; acetic; acid; fluorine; temperature; purifying; means; chromatography; ethyl; acetate; eluent; disclosed; non-radioactive; 4-fluoroantipyrine; molecular; purified; chromotography; acetic acid; nuclear medicine; ethyl acetate; specific activity; radioactive compound; active compound; direct fluorination; novel radioactive; diagnostic applications; /424/376/999/
Citation Formats
Shiue, Chyng-Yann, and Wolf, Alfred P. .sup.18 F-4-Fluoroantipyrine. United States: N. p., 1984.
Web.
Shiue, Chyng-Yann, & Wolf, Alfred P. .sup.18 F-4-Fluoroantipyrine. United States.
Shiue, Chyng-Yann, and Wolf, Alfred P. Tue .
".sup.18 F-4-Fluoroantipyrine". United States. https://www.osti.gov/servlets/purl/864913.
@article{osti_864913,
title = {.sup.18 F-4-Fluoroantipyrine},
author = {Shiue, Chyng-Yann and Wolf, Alfred P},
abstractNote = {The novel radioactive compound .sup.18 F-4-fluoroantipyrine having high specific activity which can be used in nuclear medicine in diagnostic applications, prepared by the direct fluorination of antipyrine in acetic acid with radioactive fluorine at room temperature and purifying said radioactive compound by means of gel chromatography with ethyl acetate as eluent is disclosed. The non-radioactive 4-fluoroantipyrine can also be prepared by the direct fluorination of antipyrine in acetic acid with molecular fluorine at room temperature and purified by means of gel chromotography with ethyl acetate eluent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1984},
month = {3}
}
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