Synthetic substrates for enzyme analysis

Bissell, Eugene R; Mitchell, Alexander R; Pearson, Karen W; Smith, Robert E

Title: Synthetic substrates for enzyme analysis

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Abstract

Synthetic substrates are provided which may be represented as A-D. The A moiety thereof includes an amino acid, polypeptide, or derivative thereof. The D moiety thereof includes 7-amino coumarin derivatives having an electron withdrawing substituent group at the 3 position carbon or fused between the 3 and 4 position carbons.

Inventors:

Bissell, Eugene R ^[1]; Mitchell, Alexander R ^[2]; Pearson, Karen W ^[2]; Smith, Robert E ^[2]

Alamo, CA
Livermore, CA

Issue Date:: 1983-01-01

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

OSTI Identifier:: 864578

Patent Number(s):: 4388233

Assignee:: Regents of University of California (Berkeley, CA)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
C07D311/16 - substituted in position 7
C07D311/80 - Dibenzopyrans

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K5/06086 - {with the first amino acid being basic}
C07K5/0806 - {the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala}
C07K5/0815 - {with the first amino acid being basic}

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/34 - involving hydrolase
C12Q2337/20 - Coumarin derivatives

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DOE Contract Number:: W-7405-ENG-48

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: synthetic; substrates; enzyme; analysis; provided; represented; a-d; moiety; amino; acid; polypeptide; derivative; 7-amino; coumarin; derivatives; electron; withdrawing; substituent; position; carbon; fused; carbons; amino acid; enzyme analysis; coumarin derivatives; synthetic substrates; /530/260/999/

Citation Formats


                    Bissell, Eugene R, Mitchell, Alexander R, Pearson, Karen W, and Smith, Robert E. Synthetic substrates for enzyme analysis.  United States: N. p., 1983. 
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                    Bissell, Eugene R, Mitchell, Alexander R, Pearson, Karen W, & Smith, Robert E. Synthetic substrates for enzyme analysis.  United States.

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                    Bissell, Eugene R, Mitchell, Alexander R, Pearson, Karen W, and Smith, Robert E. Sat .  
        "Synthetic substrates for enzyme analysis".  United States.  https://www.osti.gov/servlets/purl/864578.

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@article{osti_864578,

  title        = {Synthetic substrates for enzyme analysis},

  author       = {Bissell, Eugene R and Mitchell, Alexander R and Pearson, Karen W and Smith, Robert E},

  abstractNote = {Synthetic substrates are provided which may be represented as A-D. The A moiety thereof includes an amino acid, polypeptide, or derivative thereof. The D moiety thereof includes 7-amino coumarin derivatives having an electron withdrawing substituent group at the 3 position carbon or fused between the 3 and 4 position carbons.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1983},

  month        = {1}

}

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Synthetic substrates are provided which may be represented as A-D. The A moiety includes an amino acid, polypeptide, or derivative. The D moiety includes 7-amino coumarin derivatives having an electron withdrawing substituent group at the 3 position carbon or fused between the 3 and 4 position carbons. No Drawings

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