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Title: Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor

Abstract

The disclosure relates to the radioiodination of rose bengal at room temperature and a cold-kit therefor. A purified rose bengal tablet is stirred into acidified ethanol at or near room temperature, until a suspension forms. Reductant-free .sup.125 I.sup.- is added and the resulting mixture stands until the exchange label reaction occurs at room temperature. A solution of sterile isotonic phosphate buffer and sodium hydroxide is added and the final resulting mixture is sterilized by filtration.

Inventors:
 [1];  [2];  [3]
  1. (Los Alamos, NM)
  2. Sausolito, CA
  3. Los Alamos, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
OSTI Identifier:
864036
Patent Number(s):
4298591
Assignee:
United States of America as represented by United States (Washington, DC)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
instantaneous; radioiodination; rose; bengal; temperature; cold; kit; disclosure; relates; cold-kit; purified; tablet; stirred; acidified; ethanol; near; suspension; forms; reductant-free; 125; added; resulting; mixture; stands; exchange; label; reaction; occurs; solution; sterile; isotonic; phosphate; buffer; sodium; hydroxide; final; sterilized; filtration; sodium hydroxide; resulting mixture; disclosure relates; reaction occurs; rose bengal; reaction occur; /424/422/999/

Citation Formats

O'Brien, Jr., Harold A., Hupf, Homer B, and Wanek, Philip M. Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor. United States: N. p., 1981. Web.
O'Brien, Jr., Harold A., Hupf, Homer B, & Wanek, Philip M. Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor. United States.
O'Brien, Jr., Harold A., Hupf, Homer B, and Wanek, Philip M. Thu . "Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor". United States. https://www.osti.gov/servlets/purl/864036.
@article{osti_864036,
title = {Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor},
author = {O'Brien, Jr., Harold A. and Hupf, Homer B and Wanek, Philip M},
abstractNote = {The disclosure relates to the radioiodination of rose bengal at room temperature and a cold-kit therefor. A purified rose bengal tablet is stirred into acidified ethanol at or near room temperature, until a suspension forms. Reductant-free .sup.125 I.sup.- is added and the resulting mixture stands until the exchange label reaction occurs at room temperature. A solution of sterile isotonic phosphate buffer and sodium hydroxide is added and the final resulting mixture is sterilized by filtration.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1981},
month = {1}
}