Generator for gallium-68 and compositions obtained therefrom

Neirinckx, Rudi D; Davis, Michael A

Title: Generator for gallium-68 and compositions obtained therefrom

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Abstract

A generator for obtaining radioactive gallium-68 from germanium-68 bound in a resin containing unsubstituted phenolic hydroxyl groups. The germanium-68 is loaded into the resin from an aqueous solution of the germanium-68. A physiologically acceptable solution of gallium-68 having an activity of 0.1 to 50 millicuries per milliliter of gallium-68 solution is obtained. The solution is obtained from the bound germanium-68 which forms gallium-68 in situ by eluting the column with a hydrochloric acid solution to form an acidic solution of gallium-68. The acidic solution of gallium-68 can be neutralized.

Inventors:

Neirinckx, Rudi D ^[1]; Davis, Michael A ^[2]

Medfield, MA
Westwood, MA

Issue Date:: 1981-01-01

OSTI Identifier:: 863870

Patent Number(s):: 4264468

Assignee:: Massachusetts Institute of Technology (Cambridge, MA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2123/00 - Preparations for testing in vivo
A61K51/1282 - {Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents}

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G1/04 - outside nuclear reactors or particle accelerators

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DOE Contract Number:: E(11-1)-4115

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: generator; gallium-68; compositions; obtained; therefrom; obtaining; radioactive; germanium-68; bound; resin; containing; unsubstituted; phenolic; hydroxyl; loaded; aqueous; solution; physiologically; acceptable; activity; 50; millicuries; milliliter; forms; situ; eluting; column; hydrochloric; acid; form; acidic; neutralized; resin containing; phenolic hydroxyl; hydrochloric acid; acid solution; aqueous solution; acidic solution; acceptable solution; physiologically acceptable; /424/250/376/422/423/976/

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                    Neirinckx, Rudi D, and Davis, Michael A. Generator for gallium-68 and compositions obtained therefrom.  United States: N. p., 1981. 
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                    Neirinckx, Rudi D, & Davis, Michael A. Generator for gallium-68 and compositions obtained therefrom.  United States.

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                    Neirinckx, Rudi D, and Davis, Michael A. Thu .  
        "Generator for gallium-68 and compositions obtained therefrom".  United States.  https://www.osti.gov/servlets/purl/863870.

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@article{osti_863870,

  title        = {Generator for gallium-68 and compositions obtained therefrom},

  author       = {Neirinckx, Rudi D and Davis, Michael A},

  abstractNote = {A generator for obtaining radioactive gallium-68 from germanium-68 bound in a resin containing unsubstituted phenolic hydroxyl groups. The germanium-68 is loaded into the resin from an aqueous solution of the germanium-68. A physiologically acceptable solution of gallium-68 having an activity of 0.1 to 50 millicuries per milliliter of gallium-68 solution is obtained. The solution is obtained from the bound germanium-68 which forms gallium-68 in situ by eluting the column with a hydrochloric acid solution to form an acidic solution of gallium-68. The acidic solution of gallium-68 can be neutralized.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1981},

  month        = {1}

}

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