Method of freezing living cells and tissues with improved subsequent survival

Senkan, Selim M; Hirsch, Gerald P

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Title: Method of freezing living cells and tissues with improved subsequent survival

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Abstract

This invention relates to an improved method for freezing red blood cells, ther living cells, or tissues with improved subsequent survival, wherein constant-volume freezing is utilized that results in significantly improved survival compared with constant-pressure freezing; optimization is attainable through the use of different vessel geometries, cooling baths and warming baths, and sample concentrations.

Inventors:

Senkan, Selim M ^[1]; Hirsch, Gerald P ^[1]

Oak Ridge, TN

Issue Date:: 1980-01-01

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:: 863562

Patent Number(s):: 4199022

Assignee:: United States of America as represented by Department of Energy (Washington, DC)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A01 - AGRICULTURE A01N - PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

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A - HUMAN NECESSITIES A01 - AGRICULTURE A01N - PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF
A01N1/02 - Preservation of living parts
A01N1/0221 - {Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents}

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N1/04 - Preserving or maintaining viable microorganisms

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Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: method; freezing; living; cells; tissues; improved; subsequent; survival; relates; blood; constant-volume; utilized; results; significantly; compared; constant-pressure; optimization; attainable; vessel; geometries; cooling; baths; warming; sample; concentrations; significantly improved; living cells; blood cells; improved method; blood cell; subsequent survival; improved subsequent; significantly improve; /435/62/424/

Citation Formats


                    Senkan, Selim M, and Hirsch, Gerald P. Method of freezing living cells and tissues with improved subsequent survival.  United States: N. p., 1980. 
        Web.

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                    Senkan, Selim M, & Hirsch, Gerald P. Method of freezing living cells and tissues with improved subsequent survival.  United States.

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                    Senkan, Selim M, and Hirsch, Gerald P. Tue .  
        "Method of freezing living cells and tissues with improved subsequent survival".  United States.  https://www.osti.gov/servlets/purl/863562.

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@article{osti_863562,

  title        = {Method of freezing living cells and tissues with improved subsequent survival},

  author       = {Senkan, Selim M and Hirsch, Gerald P},

  abstractNote = {This invention relates to an improved method for freezing red blood cells, ther living cells, or tissues with improved subsequent survival, wherein constant-volume freezing is utilized that results in significantly improved survival compared with constant-pressure freezing; optimization is attainable through the use of different vessel geometries, cooling baths and warming baths, and sample concentrations.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1980},

  month        = {1}

}

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