Removal of plutonium from hepatic tissue

Title: Removal of plutonium from hepatic tissue

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Abstract

A method is provided for removing plutonium from hepatic tissues by introducing into the body and blood stream a solution of the complexing agent DTPA and an adjunct thereto. The adjunct material induces aberrations in the hepatic tissue cells and removes intracellularly deposited plutonium which is normally unavailable for complexation with the DTPA. Once the intracellularly deposited plutonium has been removed from the cell by action of the adjunct material, it can be complexed with the DTPA present in the blood stream and subsequently removed from the body by normal excretory processes.

Inventors:

Lindenbaum, Arthur ^[1]; Rosenthal, Marcia W ^[2]

Lockport, IL
La Grange, IL

Issue Date:: 1979-01-01

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL

OSTI Identifier:: 863305

Patent Number(s):: 4143131

Assignee:: United States of America as represented by United States (Washington, DC)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/195 - having an amino group
A61K31/135 - having aromatic rings {, e.g. ketamine, nortriptyline
A61K31/765 - Polymers containing oxygen

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S514/889 - Interferon inducer

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Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: removal; plutonium; hepatic; tissue; method; provided; removing; tissues; introducing; blood; stream; solution; complexing; agent; dtpa; adjunct; thereto; material; induces; aberrations; cells; removes; intracellularly; deposited; normally; unavailable; complexation; removed; cell; action; complexed; subsequently; normal; excretory; processes; subsequently removed; complexing agent; subsequently remove; blood stream; hepatic tissue; /514/

Citation Formats


                    Lindenbaum, Arthur, and Rosenthal, Marcia W. Removal of plutonium from hepatic tissue.  United States: N. p., 1979. 
        Web.

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                    Lindenbaum, Arthur, & Rosenthal, Marcia W. Removal of plutonium from hepatic tissue.  United States.

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                    Lindenbaum, Arthur, and Rosenthal, Marcia W. Mon .  
        "Removal of plutonium from hepatic tissue".  United States.  https://www.osti.gov/servlets/purl/863305.

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@article{osti_863305,

  title        = {Removal of plutonium from hepatic tissue},

  author       = {Lindenbaum, Arthur and Rosenthal, Marcia W},

  abstractNote = {A method is provided for removing plutonium from hepatic tissues by introducing into the body and blood stream a solution of the complexing agent DTPA and an adjunct thereto. The adjunct material induces aberrations in the hepatic tissue cells and removes intracellularly deposited plutonium which is normally unavailable for complexation with the DTPA. Once the intracellularly deposited plutonium has been removed from the cell by action of the adjunct material, it can be complexed with the DTPA present in the blood stream and subsequently removed from the body by normal excretory processes.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1979},

  month        = {1}

}

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