Low toxicity method of inhibiting sickling of sickle erythrocytes
Abstract
A low toxicity method of inhibiting sickling of sickle erythrocytes which comprises intermixing the erythrocytes with an effective anti-sickling amount of a water-soluble imidoester of the formula RC(=NH)OR' wherein R is an alkyl group of 1 - 8 carbon atoms, particularly 1 - 4 carbon atoms, and R' is an alkyl group of 1 - 4 carbon atoms, specifically methyl or ethyl acetimidate.
- Inventors:
-
- Orinda, CA
- Oakland, CA
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- OSTI Identifier:
- 862920
- Patent Number(s):
- 4048325
- Assignee:
- United States of America as represented by United States Energy (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- toxicity; method; inhibiting; sickling; sickle; erythrocytes; comprises; intermixing; effective; anti-sickling; amount; water-soluble; imidoester; formula; nh; alkyl; carbon; atoms; particularly; specifically; methyl; ethyl; acetimidate; carbon atoms; carbon atom; sickle erythrocytes; toxicity method; inhibiting sickling; /514/435/
Citation Formats
Packer, Lester, and Bymun, Edwin N. Low toxicity method of inhibiting sickling of sickle erythrocytes. United States: N. p., 1977.
Web.
Packer, Lester, & Bymun, Edwin N. Low toxicity method of inhibiting sickling of sickle erythrocytes. United States.
Packer, Lester, and Bymun, Edwin N. Sat .
"Low toxicity method of inhibiting sickling of sickle erythrocytes". United States. https://www.osti.gov/servlets/purl/862920.
@article{osti_862920,
title = {Low toxicity method of inhibiting sickling of sickle erythrocytes},
author = {Packer, Lester and Bymun, Edwin N},
abstractNote = {A low toxicity method of inhibiting sickling of sickle erythrocytes which comprises intermixing the erythrocytes with an effective anti-sickling amount of a water-soluble imidoester of the formula RC(=NH)OR' wherein R is an alkyl group of 1 - 8 carbon atoms, particularly 1 - 4 carbon atoms, and R' is an alkyl group of 1 - 4 carbon atoms, specifically methyl or ethyl acetimidate.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 1977},
month = {Sat Jan 01 00:00:00 EST 1977}
}
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