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Title: Low toxicity method of inhibiting sickling of sickle erythrocytes

Abstract

A low toxicity method of inhibiting sickling of sickle erythrocytes which comprises intermixing the erythrocytes with an effective anti-sickling amount of a water-soluble imidoester of the formula RC(=NH)OR' wherein R is an alkyl group of 1 - 8 carbon atoms, particularly 1 - 4 carbon atoms, and R' is an alkyl group of 1 - 4 carbon atoms, specifically methyl or ethyl acetimidate.

Inventors:
 [1];  [2]
  1. Orinda, CA
  2. Oakland, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
862920
Patent Number(s):
4048325
Assignee:
United States of America as represented by United States Energy (Washington, DC)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
toxicity; method; inhibiting; sickling; sickle; erythrocytes; comprises; intermixing; effective; anti-sickling; amount; water-soluble; imidoester; formula; nh; alkyl; carbon; atoms; particularly; specifically; methyl; ethyl; acetimidate; carbon atoms; carbon atom; sickle erythrocytes; toxicity method; inhibiting sickling; /514/435/

Citation Formats

Packer, Lester, and Bymun, Edwin N. Low toxicity method of inhibiting sickling of sickle erythrocytes. United States: N. p., 1977. Web.
Packer, Lester, & Bymun, Edwin N. Low toxicity method of inhibiting sickling of sickle erythrocytes. United States.
Packer, Lester, and Bymun, Edwin N. Sat . "Low toxicity method of inhibiting sickling of sickle erythrocytes". United States. https://www.osti.gov/servlets/purl/862920.
@article{osti_862920,
title = {Low toxicity method of inhibiting sickling of sickle erythrocytes},
author = {Packer, Lester and Bymun, Edwin N},
abstractNote = {A low toxicity method of inhibiting sickling of sickle erythrocytes which comprises intermixing the erythrocytes with an effective anti-sickling amount of a water-soluble imidoester of the formula RC(=NH)OR' wherein R is an alkyl group of 1 - 8 carbon atoms, particularly 1 - 4 carbon atoms, and R' is an alkyl group of 1 - 4 carbon atoms, specifically methyl or ethyl acetimidate.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1977},
month = {1}
}

Patent:

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