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Title: Method of encapsulating polyaminopolycarboxylic acid chelating agents in liposomes

Abstract

A method is provided for transferring a polyaminopolycarboxylic acid chelating agent across a cellular membrane by encapsulating the charged chelating agent within liposomes, which liposomes will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. The chelating agent is encapsulated within liposomes by drying a lipid mixture to form a thin film and wetting the lipid film with a solution containing the chelating agent. Mixing then results in the formation of a suspension of liposomes encapsulating the chelating agent, which liposomes can then be separated.

Inventors:
 [1]
  1. Downers Grove, IL
Issue Date:
Research Org.:
UNITED STATES ATOMIC ENERGY COMMISSION
OSTI Identifier:
862792
Patent Number(s):
4016290
Application Number:
05/630,474
Assignee:
United States of America as represented by United States Energy (Washington, DC)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; encapsulating; polyaminopolycarboxylic; acid; chelating; agents; liposomes; provided; transferring; agent; cellular; membrane; charged; cells; encapsulated; drying; lipid; mixture; form; film; wetting; solution; containing; mixing; results; formation; suspension; separated; cellular membrane; solution containing; chelating agents; chelating agent; carboxylic acid; charged chelating; aminopolycarboxylic acid; polyaminopolycarboxylic acid; acid chelating; /514/264/428/

Citation Formats

Rahman, Yueh Erh. Method of encapsulating polyaminopolycarboxylic acid chelating agents in liposomes. United States: N. p., 1977. Web.
Rahman, Yueh Erh. Method of encapsulating polyaminopolycarboxylic acid chelating agents in liposomes. United States.
Rahman, Yueh Erh. Thu . "Method of encapsulating polyaminopolycarboxylic acid chelating agents in liposomes". United States. https://www.osti.gov/servlets/purl/862792.
@article{osti_862792,
title = {Method of encapsulating polyaminopolycarboxylic acid chelating agents in liposomes},
author = {Rahman, Yueh Erh},
abstractNote = {A method is provided for transferring a polyaminopolycarboxylic acid chelating agent across a cellular membrane by encapsulating the charged chelating agent within liposomes, which liposomes will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. The chelating agent is encapsulated within liposomes by drying a lipid mixture to form a thin film and wetting the lipid film with a solution containing the chelating agent. Mixing then results in the formation of a suspension of liposomes encapsulating the chelating agent, which liposomes can then be separated.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1977},
month = {11}
}

Patent:

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