Liposome-encapsulated actinomycin for cancer chemotherapy
Abstract
An improved method is provided for chemotherapy of malignant tumors by injection of antitumor drugs. The antitumor drug is encapsulated within liposomes and the liposomes containing the encapsulated drug are injected into the body. The encapsulated drug penetrates into the tumor cells where the drug is slowly released and induces degeneration and death of the tumor cells, while any toxicity to the host body is reduced. Liposome encapsulation of actinomycin D has been found to be particularly effective in treating cancerous abdominal tumors, while drastically reducing the toxicity of actinomycin D to the host.
- Inventors:
-
- Downers Grove, IL
- Issue Date:
- Research Org.:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- OSTI Identifier:
- 862712
- Patent Number(s):
- 3993754
- Assignee:
- United States of America as represented by United States Energy (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- W-31109-ENG-38
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- liposome-encapsulated; actinomycin; cancer; chemotherapy; improved; method; provided; malignant; tumors; injection; antitumor; drugs; drug; encapsulated; liposomes; containing; injected; penetrates; tumor; cells; slowly; released; induces; degeneration; death; toxicity; host; reduced; liposome; encapsulation; found; particularly; effective; treating; cancerous; abdominal; drastically; reducing; improved method; tumor cells; particularly effective; antitumor drug; malignant tumors; liposomes containing; liposome encapsulation; /514/424/
Citation Formats
Rahman, Yueh-Erh, and Cerny, Elizabeth A. Liposome-encapsulated actinomycin for cancer chemotherapy. United States: N. p., 1976.
Web.
Rahman, Yueh-Erh, & Cerny, Elizabeth A. Liposome-encapsulated actinomycin for cancer chemotherapy. United States.
Rahman, Yueh-Erh, and Cerny, Elizabeth A. Thu .
"Liposome-encapsulated actinomycin for cancer chemotherapy". United States. https://www.osti.gov/servlets/purl/862712.
@article{osti_862712,
title = {Liposome-encapsulated actinomycin for cancer chemotherapy},
author = {Rahman, Yueh-Erh and Cerny, Elizabeth A},
abstractNote = {An improved method is provided for chemotherapy of malignant tumors by injection of antitumor drugs. The antitumor drug is encapsulated within liposomes and the liposomes containing the encapsulated drug are injected into the body. The encapsulated drug penetrates into the tumor cells where the drug is slowly released and induces degeneration and death of the tumor cells, while any toxicity to the host body is reduced. Liposome encapsulation of actinomycin D has been found to be particularly effective in treating cancerous abdominal tumors, while drastically reducing the toxicity of actinomycin D to the host.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1976},
month = {1}
}
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