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Title: Liposome-encapsulated actinomycin for cancer chemotherapy

Abstract

An improved method is provided for chemotherapy of malignant tumors by injection of antitumor drugs. The antitumor drug is encapsulated within liposomes and the liposomes containing the encapsulated drug are injected into the body. The encapsulated drug penetrates into the tumor cells where the drug is slowly released and induces degeneration and death of the tumor cells, while any toxicity to the host body is reduced. Liposome encapsulation of actinomycin D has been found to be particularly effective in treating cancerous abdominal tumors, while drastically reducing the toxicity of actinomycin D to the host.

Inventors:
 [1];  [1]
  1. Downers Grove, IL
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
OSTI Identifier:
862712
Patent Number(s):
3993754
Assignee:
United States of America as represented by United States Energy (Washington, DC)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
liposome-encapsulated; actinomycin; cancer; chemotherapy; improved; method; provided; malignant; tumors; injection; antitumor; drugs; drug; encapsulated; liposomes; containing; injected; penetrates; tumor; cells; slowly; released; induces; degeneration; death; toxicity; host; reduced; liposome; encapsulation; found; particularly; effective; treating; cancerous; abdominal; drastically; reducing; improved method; tumor cells; particularly effective; antitumor drug; malignant tumors; liposomes containing; liposome encapsulation; /514/424/

Citation Formats

Rahman, Yueh-Erh, and Cerny, Elizabeth A. Liposome-encapsulated actinomycin for cancer chemotherapy. United States: N. p., 1976. Web.
Rahman, Yueh-Erh, & Cerny, Elizabeth A. Liposome-encapsulated actinomycin for cancer chemotherapy. United States.
Rahman, Yueh-Erh, and Cerny, Elizabeth A. Thu . "Liposome-encapsulated actinomycin for cancer chemotherapy". United States. https://www.osti.gov/servlets/purl/862712.
@article{osti_862712,
title = {Liposome-encapsulated actinomycin for cancer chemotherapy},
author = {Rahman, Yueh-Erh and Cerny, Elizabeth A},
abstractNote = {An improved method is provided for chemotherapy of malignant tumors by injection of antitumor drugs. The antitumor drug is encapsulated within liposomes and the liposomes containing the encapsulated drug are injected into the body. The encapsulated drug penetrates into the tumor cells where the drug is slowly released and induces degeneration and death of the tumor cells, while any toxicity to the host body is reduced. Liposome encapsulation of actinomycin D has been found to be particularly effective in treating cancerous abdominal tumors, while drastically reducing the toxicity of actinomycin D to the host.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1976},
month = {1}
}

Patent:

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