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Title: Liposome encapsulation of chelating agents

Abstract

A method for transferring a chelating agent across a cellular membrane by encapsulating the charged chelating agent within liposomes and carrying the liposome-encapsulated chelating agent to the cellular membrane where the liposomes containing the chelating agent will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. A chelating agent can be introduced into the interior of a cell of a living organism wherein the liposomes will be decomposed, releasing the chelating agent to the interior of the cell. The released chelating agent will complex intracellularly deposited toxic heavy metals, permitting the more soluble metal complex to transfer across the cellular membrane from the cell and subsequently be removed from the living organism.

Inventors:
 [1]
  1. Downers Grove, IL
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
OSTI Identifier:
862445
Patent Number(s):
3932657
Application Number:
05/415,077
Assignee:
United States of America as represented by United States Energy (Washington, DC)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
liposome; encapsulation; chelating; agents; method; transferring; agent; cellular; membrane; encapsulating; charged; liposomes; carrying; liposome-encapsulated; containing; cells; introduced; interior; cell; living; organism; decomposed; releasing; released; complex; intracellularly; deposited; toxic; heavy; metals; permitting; soluble; metal; transfer; subsequently; removed; cellular membrane; heavy metal; chelating agents; chelating agent; heavy metals; soluble metal; metal complex; charged chelating; liposomes containing; liposome encapsulation; /514/

Citation Formats

Rahman, Yueh Erh. Liposome encapsulation of chelating agents. United States: N. p., 1976. Web.
Rahman, Yueh Erh. Liposome encapsulation of chelating agents. United States.
Rahman, Yueh Erh. Tue . "Liposome encapsulation of chelating agents". United States. https://www.osti.gov/servlets/purl/862445.
@article{osti_862445,
title = {Liposome encapsulation of chelating agents},
author = {Rahman, Yueh Erh},
abstractNote = {A method for transferring a chelating agent across a cellular membrane by encapsulating the charged chelating agent within liposomes and carrying the liposome-encapsulated chelating agent to the cellular membrane where the liposomes containing the chelating agent will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. A chelating agent can be introduced into the interior of a cell of a living organism wherein the liposomes will be decomposed, releasing the chelating agent to the interior of the cell. The released chelating agent will complex intracellularly deposited toxic heavy metals, permitting the more soluble metal complex to transfer across the cellular membrane from the cell and subsequently be removed from the living organism.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1976},
month = {1}
}

Patent:

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