Iridium 191-m generator

Treves, S; Cheng, C C

Title: Iridium 191-m generator

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Abstract

Potassium osmate, of the formula K[sub 2]OsO[sub 2](OH)[sub 4], is used to make a column for the generation of Ir-191 m, which is used in first pass angiography to detect cardiac defects in patients. 2 figs.

Inventors:: Treves, S; Cheng, C C

Issue Date:: 1988-03-08

Research Org.:: Childrens Hospital Corp

OSTI Identifier:: 7265340

Patent Number(s):: 4729380

Application Number:: PPN: US 6-492336

Assignee:: Children's Medical Center Corp., Boston, MA (United States)

DOE Contract Number:: AC02-82ER60084

Resource Type:: Patent

Resource Relation:: Patent File Date: 6 May 1983

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; CARDIOVASCULAR DISEASES; DIAGNOSIS; RADIOISOTOPE GENERATORS; DESIGN; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; ISOTOPE PRODUCTION; DISEASES; DRUGS; LABELLED COMPOUNDS; SYNTHESIS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

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                    Treves, S, and Cheng, C C. Iridium 191-m generator.  United States: N. p., 1988. 
        Web.

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                    Treves, S, & Cheng, C C. Iridium 191-m generator.  United States.

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                    Treves, S, and Cheng, C C. Tue .  
        "Iridium 191-m generator".  United States.

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@article{osti_7265340,

  title        = {Iridium 191-m generator},

  author       = {Treves, S and Cheng, C C},

  abstractNote = {Potassium osmate, of the formula K[sub 2]OsO[sub 2](OH)[sub 4], is used to make a column for the generation of Ir-191 m, which is used in first pass angiography to detect cardiac defects in patients. 2 figs.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1988},

  month        = {3}

}

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Iridium 191-M generator

Patent Treves, Salvador [Newton, MA]; Cheng, Chris C [Brookline, MA]

Potassium osmate, of the formula K.sub.2 Os O.sub.2 (OH).sub.4), used to make a column for the generation of Ir-191 m, which is used in first pass angiography to detect cardiac defects in patients.
Full Text Available
Osmium-191/iridium-191m radionuclide

Patent Knapp, Jr, F F; Butler, T A; Brihaye, C

A generator system to provide iridium-191m for clinical imaging applications comprises an activated carbon adsorbent loaded with a compound containing the parent nuclide, osmium-191. The generator, which has a shelf-life in excess of two weeks and does not require a scavenger column, can be eluted with physiologically compatible saline. 4 figs. 3 tabs.
(Uses of iridium 191 from the osmium 191/iridium 191 generator system)

Technical Report Knapp, Jr, F F

The traveler was an invited speaker at the 30th Commemorative Meeting of the Finnish Society of Nuclear Medicine on March 2--3 in Helsinki, Finland. He described the development, initial clinical applications, and future use of iridium-191m from the osmium-191/-iridium-191m generator system developed at the Oak Ridge National Laboratory (ORNL). He also visited the university hospitals in Kupio and Turku, Finland, and presented seminars on the use of iridium-191m and iodine-123-labeled fatty acids for cardiac studies. He visited the Clinic for Nuclear Medicine in Bonn, West Germany, and the Cyclotron Research Center (CRC) in Liege, Belgium, to coordinate collaborative projects onmore » « less
Osmium-191. -->. iridium-191m radionuclide generator: development and clinical application. Progress report, March 1, 1981-February 28, 1982

Technical Report Treves, S; Cheng, C

A prototype osmium-191 (T 1/2 = 16 days) ..-->.. iridium-191m (T 1/2 = 4.9 seconds) generator designed for first pass radionuclide angiography was developed in our laboratory (Os-191 ..-->.. Ir-191m). Our generator had 14 to 20% Ir-191m yield and a 1 to 3 x 10/sup -3/% Os-191 breakthrough. Iridium-191m decays with emission of a 65 and a 129 keV photon in 50% and 25% abundance respectively. This radionuclide is advantageous for angiography since it provides higher photon flux and results in much lower radiation dose to the patient than Tc-99m. One objective of this research is to improve the Os-191more » « less
Development of a new osmium-191-iridium-191m radionuclide generator. Annual report

Technical Report Treves, S; Packard, A B

The major limitation of the Cheng generator design is the chemical instability of the parent trans-dioxotetrachloroosmate(VI) complex. Efforts reported here were directed towards the evaluation of alternative osmium complexes for use as the parent species. Several non-chloro osmium complexes were synthesized that proved to be promising for generator applications and /sup 191/Os-/sup 191m/Ir generators were subsequently developed using these complexes as the parent species. One of these generators (''oxalate'') was found to be particularly promising and has been optimized for potential human use (IND application pending). Although the ''oxalate'' generator provides twice the /sup 191m/Ir yield and less than one-tenthmore » « less

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