Polycatecholamide chelating agents
Abstract
Novel polybenzamide compounds useful for in vitro or in vivo chelation are described. The compounds have the formula given in patent. Polyamines are reacted with 2,3-dimethoxy benzoyl chloride unsubstituted or substituted with SO[sub 3]H, SO[sub 3]M, NO[sub 2], CO[sub 2]H or CO[sub 2]M as desired is reacted with a polyamine in an inert solvent then demethylated with BBr[sub 3] or BCl[sub 3] in an inert solvent. Where compounds symmetrically substituted on the terminal N's are desired, the polyamine is first reductively alkylated by reaction with an aldehyde or ketone and the resulting Schiff base is hydrogenated. No Drawings
- Inventors:
- Issue Date:
- OSTI Identifier:
- 7254118
- Patent Number(s):
- 4442305
- Application Number:
- PPN: US 6-295512
- Assignee:
- Dept. of Energy, Washington, DC (United States)
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 24 Aug 1981
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; CHELATING AGENTS; CHEMICAL PREPARATION; ALKYLATION; CHEMICAL REACTIONS; SCHIFF BASES; IMINES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; SYNTHESIS; 550600* - Medicine
Citation Formats
Weitl, F L, and Raymond, K N. Polycatecholamide chelating agents. United States: N. p., 1984.
Web.
Weitl, F L, & Raymond, K N. Polycatecholamide chelating agents. United States.
Weitl, F L, and Raymond, K N. Tue .
"Polycatecholamide chelating agents". United States.
@article{osti_7254118,
title = {Polycatecholamide chelating agents},
author = {Weitl, F L and Raymond, K N},
abstractNote = {Novel polybenzamide compounds useful for in vitro or in vivo chelation are described. The compounds have the formula given in patent. Polyamines are reacted with 2,3-dimethoxy benzoyl chloride unsubstituted or substituted with SO[sub 3]H, SO[sub 3]M, NO[sub 2], CO[sub 2]H or CO[sub 2]M as desired is reacted with a polyamine in an inert solvent then demethylated with BBr[sub 3] or BCl[sub 3] in an inert solvent. Where compounds symmetrically substituted on the terminal N's are desired, the polyamine is first reductively alkylated by reaction with an aldehyde or ketone and the resulting Schiff base is hydrogenated. No Drawings},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1984},
month = {4}
}
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